Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pyronaridine tetraphosphate 是一种具有口服活性的、含甘露醇的DNA 拓扑异构酶 2 的抑制剂和红细胞裂殖杀灭剂,具有抗疟活性和抗肿瘤活性。Pyronaridine tetraphosphate 可治疗 P. falciparum 和 Echinococcus granulosus感染,可减轻埃博拉病毒传播。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 147 | 现货 | ||
10 mg | ¥ 196 | 现货 | ||
25 mg | 特惠询价 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 347 | 现货 |
产品描述 | Pyronaridine tetraphosphate is an orally active, mannitol-containing inhibitor of DNA topoisomerase 2 and erythrocyte cytokine with antimalarial and antitumour activity.Pyronaridine tetraphosphate treats P. falciparum and Echinococcus granulosus infections. Pyronaridine tetraphosphate treats P. falciparum and Echinococcus granulosus infections and attenuates Ebola virus transmission. |
靶点活性 | P. falciparum:1.53-3.94 nM |
体外活性 | With an IC50 value of 1.53-3.94 nM, pyronaridine tetraphosphate (24 h) exhibits anti-P. falciparum activity[2]. |
体内活性 | Reducing the parasitic burden in Echinococcus granulosus-infected mice, pyronaridine tetraphosphate (57 mg/kg, oral administration, q.d. for 30 days) has been demonstrated[1].Reducing the parasitic burden in secondarily infected (cysts) mice, pyronaridine tetraphosphate (57 mg/kg, intraperitoneal injection, q.d. for 3 days) has shown efficacy[1].Exhibiting a higher exposure in the liver than in the plasma in male ICR mice, pyronaridine tetraphosphate (57 mg/kg, intraperitoneal injection, for a single dose) has been observed[1]. |
分子量 | 910.03 |
分子式 | C29H44ClN5O18P4 |
CAS No. | 76748-86-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 20 mg/mL (21.98 mM), Sonication is recommended.
DMSO: 10 mg/mL (10.99 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 1.0989 mL | 5.4943 mL | 10.9886 mL | 27.4716 mL |
5 mM | 0.2198 mL | 1.0989 mL | 2.1977 mL | 5.4943 mL | |
10 mM | 0.1099 mL | 0.5494 mL | 1.0989 mL | 2.7472 mL | |
H2O | 20 mM | 0.0549 mL | 0.2747 mL | 0.5494 mL | 1.3736 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Pyronaridine tetraphosphate 76748-86-2 DNA Damage/DNA Repair Topoisomerase Pyronaridine Inhibitor inhibitor inhibit