Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Levofloxacin hydrate (Cravit hydrate) 是抗生素化合物,抑制细菌DNA 旋转酶活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 298 | 现货 | ||
100 mg | ¥ 418 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 460 | 现货 |
产品描述 | Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth. |
细胞实验 | Cell suspension samples (50 mL) (2-5×104 mast cells in each tube for dispersed skin cells or 1 ×105 mast cells in each tube for rat peritoneal cells) in duplicate are equilibrated at 37℃ for 10 min, and then added to polypropylene tubes containing 450 mL test compounds dissolved in Tyrode solution. Histamine release reaction is allowed to proceed for a further 30 min. at the end of which time the reaction is terminated by adding 2 mL ice-cold Tyrode solution and the mixture is centrifuged (450 g for 5 min at 4℃). For determination of total histamine content, mast cells are disrupted in boiling water for 10 min. Histamine concentrations in the resulting supernatant and disrupted cells are determined by the enzyme immunoassay described above. (Only for Reference) |
别名 | 左氧氟沙星半水合物, Levaquin hydrate, Cravit hydrate, Quixin hydrate, Levofloxacin Hemihydrate, Tavanic hydrate, Iquix hydrate |
分子量 | 370.38 |
分子式 | C18H20FN3O4·1/2H2O |
CAS No. | 138199-71-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 74 mg/mL (199.79 mM)
H2O: 5 mg/mL (13.5 mM)
Ethanol: 10 mg/mL (27 mM)
Methanol: 10 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O / Ethanol / Methanol | 1 mM | 2.6999 mL | 13.4996 mL | 26.9993 mL | 67.4982 mL |
5 mM | 0.54 mL | 2.6999 mL | 5.3999 mL | 13.4996 mL | |
10 mM | 0.27 mL | 1.35 mL | 2.6999 mL | 6.7498 mL | |
DMSO / Ethanol | 20 mM | 0.135 mL | 0.675 mL | 1.35 mL | 3.3749 mL |
DMSO | 50 mM | 0.054 mL | 0.27 mL | 0.54 mL | 1.35 mL |
100 mM | 0.027 mL | 0.135 mL | 0.27 mL | 0.675 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Levofloxacin hydrate 138199-71-0 DNA Damage/DNA Repair Microbiology/Virology DNA gyrase Topoisomerase Antibacterial Antibiotic inhibit BK Viremia 左氧氟沙星半水合物 Levofloxacin Hydrate Quixin Hydrate chronic periodontitis Levaquin hydrate Inhibitor Iquix Hydrate Tavanic Hydrate Cravit hydrate Cravit Hydrate DNA/RNA Synthesis Quixin hydrate Levofloxacin Hemihydrate airway inflammation Tavanic hydrate Levofloxacin Bacterial Iquix hydrate Levaquin Hydrate inhibitor