Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cyproterone acetate (Cyproterone 17-O-acetate) 是能够抗雄激素(IC50=7.1 nM) 和孕激素合成的类固醇。它与 progesteron 和糖皮质激素受体有亲和力。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 172 | 现货 | ||
100 mg | ¥ 310 | 现货 | ||
200 mg | ¥ 483 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 345 | 现货 |
产品描述 | Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels.Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone Acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels. |
靶点活性 | Androgen receptor:7.1 nM |
体外活性 | 经Cyproterone acetate处理后,大鼠体内GST和超氧化物歧化酶活性显著降低,NO明显提高,MDA含量显著增加,反映了大鼠睾丸的氧化状态.Cyproterone acetate对生殖器官重量有直接的不良作用,且会使精子数量和 Ca2+含量显著降低.秋季人为的光照时长增加以及CA处理对精子运动及形态存在负面影响. 以Cyproterone acetate处理雄激素受体后,睾丸中精细胞鱼精蛋白水平会首先下降,核染色质浓缩过程涉及的精子水平也会下降. |
体内活性 | 在睾丸激素(10 nM)存在时,低浓度Cyproterone acetate对T-刺激的3XHRE-LUC转录具有抑制作用,高浓度作用则相反。Cyproterone acetate既有明显的拮抗性能亦有部分激活剂特性,相对浓度较高时可激活AR(EC50为4.0 μM)。 |
别名 | Androcur, 醋酸环丙氯地孕酮, Cyproterone 17-O-acetate, 醋酸环丙孕酮 |
分子量 | 416.94 |
分子式 | C24H29ClO4 |
CAS No. | 427-51-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 10 mg/mL (23.98 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 77 mg/mL (184.7 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 2.3984 mL | 11.9921 mL | 23.9843 mL | 59.9607 mL |
5 mM | 0.4797 mL | 2.3984 mL | 4.7969 mL | 11.9921 mL | |
10 mM | 0.2398 mL | 1.1992 mL | 2.3984 mL | 5.9961 mL | |
20 mM | 0.1199 mL | 0.5996 mL | 1.1992 mL | 2.998 mL | |
DMSO | 50 mM | 0.048 mL | 0.2398 mL | 0.4797 mL | 1.1992 mL |
100 mM | 0.024 mL | 0.1199 mL | 0.2398 mL | 0.5996 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cyproterone acetate 427-51-0 Endocrinology/Hormones Androgen Receptor Cyproterone DR5 hormonal cancer Androcur inhibit tumorigenesis prostate 醋酸环丙氯地孕酮 cells Cyproterone 17-O-acetate steroid Inhibitor Cyproterone Acetate 醋酸环丙孕酮 inhibitor