Name: Cephaeline dihydrochloride
Brand: TargetMol
SKU: TQ0109
Price: 594 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

2 mg

¥ 594

现货

5 mg

¥ 996

现货

10 mg

¥ 1,490

现货

25 mg

¥ 2,980

现货

50 mg

¥ 4,810

现货

1 mL x 10 mM (in DMSO)

¥ 1,180

现货

产品介绍

生物活性

产品描述	Cephaeline dihydrochloride is a naturally occurring alkaloid that is a selective CYP2D6 inhibitor with an IC50=121 μM. It has an affinity for and oral activity at the 5-HT4 receptor and is capable of inducing vomiting.
靶点活性	CYP2D6:121 μM, CYP3A4:1000 μM
体外活性	在人体肝微粒体系统中，Cephaeline dihydrochloride 对主要的细胞色素 P450 酶系表现出较弱的抑制活性。研究表明，其对 CYP2D6 的半数抑制浓度（IC₅₀）为 121 μM，抑制常数（Ki）为 54 μM，属竞争性抑制；而对 CYP3A4 的 IC₅₀ 为 1000 μM，Ki 为 355 μM，为非竞争性抑制[1]。
别名	盐酸吐根酚碱, NSC32944, NSC 32944, (-)-Cephaeline dihydrochloride

化学信息

分子量	539.53
分子式	C₂₈H₄₀Cl₂N₂O₄
CAS No.	5853-29-2
Smiles	COC(C=C(CCN1C[C@@H]2CC)C([C@]1([H])C[C@@H]2C[C@@H]3C4=CC(OC)=C(O)C=C4CCN3)=C5)=C5OC.Cl.Cl
密度	1.31g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 200 mg/mL (370.69 mM), Sonication is recommended.

H2O: 100 mg/mL (185.35 mM), Sonication is recommended.

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8535 mL	9.2673 mL	18.5347 mL	92.6733 mL
5 mM	0.3707 mL	1.8535 mL	3.7069 mL	18.5347 mL
10 mM	0.1853 mL	0.9267 mL	1.8535 mL	9.2673 mL
20 mM	0.0927 mL	0.4634 mL	0.9267 mL	4.6337 mL
50 mM	0.0371 mL	0.1853 mL	0.3707 mL	1.8535 mL
100 mM	0.0185 mL	0.0927 mL	0.1853 mL	0.9267 mL

体内实验配液计算器