Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Benzo[a]pyrene (3,4-Benzopyrene) 在动物模型中显示肺致癌性,可用于化学预防研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 417 | 现货 | ||
25 mg | ¥ 919 | 现货 | ||
50 mg | ¥ 1,378 | 现货 | ||
100 mg | ¥ 1,997 | 现货 | ||
200 mg | ¥ 3,792 | 现货 | ||
500 mg | ¥ 4,940 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 462 | 现货 |
产品描述 | Benzo[a]pyrene (3,4-Benzopyrene) shows lung carcinogenicity in mice in a dose-dependent manner. |
体内活性 | lung tumorigenesis induced by Benzo[a]pyrene(B[a]P) was dose dependent in female A/J mice.?The incidence of hyperplasia values in females treated with 0.25, 0.50, and 1.0 mg B[a]P were significantly higher than in the vehicle-treated group.?The incidence of adenoma in females receiving 1.0 mg B[a]P was significantly higher than in the vehicle group.?The multiplicity of hyperplasia in females receiving 0.50 or 1.0 mg B[a]P was significantly higher than in the vehicle group.?The multiplicity of adenoma in the group treated with 1.0 mg was also significantly higher than in the vehicle group.?The incidences of hyperplasia and adenoma in female A/J mice were significantly increased by B[a]P in a dose-dependent manner.?Proliferative lesions in the lungs were classified as bronchiolar-alveolar hyperplasia or adenoma, and no malignant neoplasms (adenocarcinoma) were observed[1]. |
动物实验 | After a 1- or 2-week acclimatization period, 360 adult male A/J mice and 520 adult female A/J mice were used for the experiment.?Mice were allocated, using a body weight-based randomization process, to a total of 22 groups.?Briefly, each animal received a single intraperitoneal administration of one of the initiators, at one of the indicated doses, on day 1.?The animals were observed daily for clinical signs and mortality, and body weights were measured weekly.?Following an overnight fast at 26 weeks after dosing, all mice were anesthetized with sevoflurane and weighed.?They were then sacrificed by exsanguination from the abdominal aorta and caudal vena cava and subjected to necropsy[1]. |
别名 | 苯并[a]芘, 3,4-Benzopyrene, 苯并(a)芘 |
化合物与蛋白结合的复合物 |
Solution Structure of a Trans-Opened (10S)-dA Adduct of (+)-(7S,8R,9S,10R)-7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a fully Complementary DNA Duplex |
分子量 | 252.31 |
分子式 | C20H12 |
CAS No. | 50-32-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9.09 mg/mL (36.03 mM ), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.9634 mL | 19.8169 mL | 39.6338 mL | 99.0845 mL |
5 mM | 0.7927 mL | 3.9634 mL | 7.9268 mL | 19.8169 mL | |
10 mM | 0.3963 mL | 1.9817 mL | 3.9634 mL | 9.9084 mL | |
20 mM | 0.1982 mL | 0.9908 mL | 1.9817 mL | 4.9542 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Benzo[a]pyrene 50-32-8 Others Inhibitor 苯并[a]芘 Endogenous Metabolite inhibit 3,4-Benzopyrene 苯并(a)芘 inhibitor