18:0 mPEG350 PE (ammonium) is a PEG lipid with functional terminal groups used in the synthesis of liposomes (LPs) for designing conjugated polymer nanoparticles. Liposome nanoparticles (LNPs), featuring biotin modification and a carboxyl terminus, enable further coupling with other biomolecules. These functionalized nanoparticles can target specific cell protein labeling. Using streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles can bind with biotinylated antibodies on cell surface receptors, providing practical applications in fluorescence-based imaging and sensing.