unii-2g25ke-3954

Amitriptan fumarate is serotonin 5HT-1B/1D receptor agonist with anti-migraine activity.

Avitriptan, also known as BMS-180048, is a selective 5-HT1-like receptor agonist. Avitriptan is an effective compound for the treatment of migraine headaches with a prolonged duration of response. Avitriptan Is a Ligand and Agonist of Human Aryl Hydrocarbon Receptor That Induces CYP1A1 in Hepatic and Intestinal Cells.

Avitriptan 是一种5-HT1B/1D受体激动剂，其pKi分别为7.44 (5-HT1Brat)、7.68 (5-HT1Bhuman)和8.36 (5-HT1Dhuman)。此化合物可收缩离体冠状动脉，并适用于偏头痛的治疗。