trp2

化合物C3N-Dbn-Trp2 作为ATP结合盒转运蛋白ABCB1的抑制剂, 在HEK293T及HCT-15细胞中，该化合物阻断了ABCB1介导的Rhodamine 123的外排作用，其IC50值分别为5.9 µM和2.2 µM。此外，C3N-Dbn-Trp2 还能抑制Doxorubicin的外排，从而提高了ABCB1表达细胞对Doxorubicin的细胞毒性响应。

Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide derived from the tyrosinase-related protein 2 (TRP-2), specifically corresponding to residues 180-188. It is the primary epitope within TRP-2 that is recognized by anti-B16 CTLs. Moreover, It is a peptide that conforms to the binding motif of the MHC class I H2-Kb.

[D-Trp2,7,9] Substance P 是一种速激肽 (Neurokinin Receptor) 拮抗剂，对 NK-1、NK-2和 NK-3受体的 Ki 值分别为 1 μM、1.3 μM 和 ~9 μM。

This peptide is a TRP-tyrosinase-related protein. Its immunization results in effective induction of antitumor immunity.