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79

抑制剂 & 化合物

53

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8575	ENFENAMIC ACID	Platelet aggregation	Others
	Enfenamic acid 是一种能够抑制伤口愈合的非甾体抗炎药。
T79791	Immunosuppressant-1	Apoptosis	Apoptosis
	Immunosuppressant-1（Compound 31）抑制抗-CD3/抗-CD28共刺激的T细胞增殖，具备免疫抑制活性。该化合物能激活活化的淋巴结细胞中的caspase-3和PARP，从而诱导细胞凋亡（apoptosis）。
T25862	Neomyosuppressin Thr-asp-val-asp-his-val-phe-leu-arg-phenh2,Dromyosuppressin,Neb-MS
	Neomyosuppressin is a myoinhibiting neuropeptide isolated from the grey fleshfly, Neobellieria bullata and Drosophila.
TP2281	p53 tumor suppressor fragment	Others	Others
	p53 tumor suppressor fragment (232-240) is a peptide with the sequence H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH, MW= 1066.3. p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where i
T25683	Leucomyosuppressin p-Glu-asp-val-asp-his-val-phe-leu-arg-phe-NH2
	Leucomyosuppressin, isolated from head extracts of the cockroach Leucophaea maderae, inhibits evoked transmitter release at the mealworm neuromuscular junction.
T5403	ULK-101	Autophagy	Autophagy
	ULK-101 是一种选择性 ULK1抑制剂，可抑制自噬，对 ULK1和 ULK2 的 IC50值分别为 8.3 nM 和 30 nM。
T7556	Fadrozole hydrochloride CGS 16949A,盐酸法倔唑	Aromatase	Endocrinology/Hormones
	Fadrozole hydrochloride (CGS 16949A) 是一种选择性的、有效，和非甾体类的芳香化酶抑制剂(IC50:6.4 nM)。
T8951	JTP 0819958 - HOIPIN-1	IκB/IKK	NF-κB
	JTP 0819958 - HOIPIN-1 是一种选择性线性泛素链组装复合物 (LUBAC) 抑制剂，IC50 为 2.8 μM。 JTP-0819958 在体外抑制 LUBAC 介导的 NF-kB 活化[2]。
T21483	Tricaine methanesulfonate 3-氨基苯甲酸乙酯甲基磺酸盐,MS-222	Others	Others
	Tricaine methanesulfonate (MS-222) 常用于固定鱼的标记和运输，并能抑制入侵过程中的感觉系统。
T11600	IBR2 Isoquinoline	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	IBR2（Isoquinoline）是一种针对RAD51的强效特异性抑制剂，通过干预RAD51多聚体形成，加速蛋白酶体介导的RAD51蛋白降解，抑制癌细胞生长并诱导凋亡。实验证明在抑制RAD51介导的DNA双链断裂修复方面有效。
T21482	Uniconazole	P450; ROS Kinase	Metabolism; Tyrosine Kinase/Adaptors
	Uniconazole 是植物生长调节剂，能够抑制细胞色素 P450 707As (Ki=68 nM)。他是分解脱落酸的酶家族成员，能够抑制赤霉素和甾醇的生物合成。
T8528	AC1903	TRP/TRPV Channel	Membrane transporter/Ion channel
	AC1903是一种选择性的TRPC5抑制剂，具有足细胞保护特性，对 TRPC4 或 TRPC6没有影响，并且在激酶谱分析中没有显示出脱靶效应。在局灶节段性肾小球硬化大鼠模型中，AC1903抑制严重蛋白尿，并且防止足细胞丢失。
T61392	NLRP3-IN-10 ZVN26391	NOD	Immunology/Inflammation; NF-κB
	NLRP3-IN-10 (ZVN26391) 是强效的 NLRP3 抑制剂，抑制 IL-1β 释放的 IC50 为 251.1 nM。NLRP3-IN-10 通过减弱 ASC 斑点形成来抑制 NLRP3炎症小体激活。
T9765	TJ-M2010-5	MyD88	Immunology/Inflammation
	TJ-M2010-5 是一种 MyD88 抑制剂，可与 TIR 结构域结合以干扰其同源二聚化并抑制 MyD88 信号传导。 TJ-M2010-5 可用于心肌缺血/再灌注损伤研究。
T9939	JMJD6 inhibitor WL12 2H-1-Benzopyran-2-one, 3-(3H-imidazo[4,5-c]pyridin-2-yl)-6-methyl-,ZINC6733033	Others	Others
	JMJD6 inhibitor WL12 (ZINC6733033) 是一种JMJD6 抑制剂，能够抑制JMJD6依赖的癌细胞增殖，包括宫颈癌细胞和肝癌细胞，为研究JMJD6在癌症发展中的生物学功能提供了一个小分子探针。
T36520	COR659	Cannabinoid Receptor; GABA Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	COR659 是一种有效的 GABAB 的阳性变构调节剂。COR659具有缓解大鼠对酒精和巧克力成瘾的作用。
T8736	Cidofovir dihydrate HPMPC,(S)-HPMPC,GS 0504,西多福韦二水合物	Others	Others
	Cidofovir dihydrate (HPMPC) 是注射型巨细胞病毒 DNA 聚合酶抑制剂，通过选择性抑制病毒 DNA 聚合酶来抑制 CMV 复制，从而阻止病毒复制和转录。
T4206	E6446	TLR	Immunology/Inflammation
	E6446 抑制 Toll 样受体 (TLR)7 和 9 信号传导。 E6446 在多种人和小鼠细胞类型中起作用，并在体外抑制 DNA-TLR9 相互作用。当给予小鼠时，该化合物抑制对刺激 TLR9 的含有胞苷-磷酸-胍 (CpG) 的 DNA 的挑战剂量的反应。
T38273	Paclobutrazol (2R,3R)-Paclobutrazol,多效唑,(R,R)-paclobutrazol,2R,3R-Paclobutrazol	Antifungal	Microbiology/Virology
	Paclobutrazol ((R,R)-paclobutrazol) 是一种含有三唑的植物生长延缓剂，能抑制赤霉素的生物合成。Paclobutrazol 还具有抗真菌 (antifungal) 活性。Paclobutrazol 能抑制脱落酸的合成，诱导植物的耐冷性植物。Paclobutrazol 通常用于赤霉素在植物生物学中作用的研究。
T2527	Ulipristal acetate Ulipristal,醋酸乌利司他,CDB-2914	Estrogen/progestogen Receptor; Progesterone Receptor; Autophagy	Autophagy; Endocrinology/Hormones; Others
	Ulipristal acetate (CDB-2914) 是一种具有抗孕酮活性的选择性孕酮受体调节剂。它可抑制子宫平滑肌瘤病的生长。它通过抑制或延迟排卵和影响子宫内膜组织，可用作紧急避孕药。
T67836	AT-533	HSP; HSV	Cytoskeletal Signaling; Metabolism; Microbiology/Virology
	AT-533 是有效的 HSV 和 Hsp90 抑制剂。AT-533 可以阻断 HIF-1α/VEGF/VEGFR-2 信号通路，从而抑制血管生成和肿瘤生长。AT-533 也抑制下游通路的激活，包括 Erk1/2, FAK, Akt/mTOR/p70S6K。AT-533 抑制人脐静脉内皮细胞 (HUVEC) 的细胞迁移、侵袭和管形成。
T9398	NSC 73150 NSC 97967	Others	Others
	6-methyl-2-[2-[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]hydraziny l]-1H-pyrimidin-4-one (NSC 73150) 是一种嘧啶衍生物，具有抗肿瘤活性，临床前研究表明，它可以抑制各种肿瘤细胞系的生长，包括乳腺癌、肺癌和肝癌，也被发现可诱导细胞凋亡、抑制血管生成和抑制肿瘤转移。
T15096	Delgocitinib JTE-052,迪高替尼,Corectim（Delgocitinib）	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Delgocitinib（JTE-052）是一种特异性的JAK（Janus激酶）抑制剂，其对JAK1、JAK2、JAK3 和 Tyk2 的 IC50 值分别为 2.8、2.6、13 和 58 nM。Delgocitinib 通过JAK-依赖性细胞因子参与多种炎症和自身免疫性疾病，能有效地遏制多种细胞因子信号传递，同时抑制了因细胞因子而引发的瘙痒。它可广泛用于治疗各种炎症性疾病，包括自身免疫性疾病和超敏反应。
T1083L	Theophylline monohydrate Quibron,茶碱一水合物	HDAC; PDE; Adenosine Receptor	Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Theophylline monohydrate (Quibron) 似乎抑制磷酸二酯酶和前列腺素的产生，调节钙通量和细胞内钙分布，并拮抗腺苷。茶碱是黄嘌呤的天然生物碱衍生物，从植物山茶花和小粒咖啡中分离出来。在生理上，该药剂可放松支气管平滑肌，产生血管舒张（脑血管除外），刺激中枢神经系统，刺激心肌，利尿，增加胃酸分泌；它还可以抑制炎症并改善横膈膜的收缩性。
T16538	PIN1 inhibitor API-1	Others	Others
	PIN1 inhibitor API-1 是特殊的 Pin1抑制剂，可直接特异性地与 Pin1 肽基脯氨酰异构酶结构域结合，并抑制 Pin1 顺反异构活性。它保留 pXPO5 的活性构象，恢复 pXPO5 将前 miRNA 从细胞核转运到细胞质的能力，从而上调抗癌 miRNA 的生物发生，抑制体内外肝癌的发生。
T0983L	DL-Penicillamine 3-Sulfanylvaline,DL-青霉胺	Antibiotic	Microbiology/Virology
	DL-Penicillamine (3-Sulfanylvaline) 是一种螯合剂，推荐用于去除威尔逊病患者体内多余的铜。它仅存在于使用或服用该药物的个体中。它是青霉素类抗生素最具特征的降解产物。它被用作抗风湿药和威尔逊病的螯合剂。
T30923	CI-1018 UNII-05127JZ9KQ
	CI-1018 is a PDE IV inhibitor that is being developed as a drug to suppress inflammation.
T23706	Alminoprofen EB382,EB 382,EB-382
	Alminoprofen is a nonsteroidal anti-inflammatory agent. It was found to significantly suppress passive anaphylactic bronchoconstrictions at 30 mg/kg given intraduodenally.
T26883	BO 2367 BO2367,BO-2367
	BO 2367, a topoisomerase inhibitor, is used to suppress the growth of tumor .
T23697	AL-8417 J1.090.276B,AL8417,(2R)-AL-5898
	AL-8417 is an enzyme inhibitor. It acting as an antioxidant, anti-inflammatory, and cytostatic agent. It also has the ability to suppress vitrectomy-induced posterior lens fiber changes.
T68884	Aplysin
	Aplysin is an antineoplastic agent. Aplysin has been shown to suppress breast cancer cell activity via inhibition of the PI3K/AKT/FOXO3a pathway. Aplysin has also been shown to protect hepatocytes against oxidative damage.
T78613	Selnoflast calcium RO-7486967 calcium	NOD-like Receptor (NLR)	Immunology/Inflammation
	Selnoflast calcium (example 6) 作为一种NLRP3抑制剂。
T28296	Parogrelil hydrochloride INDI-702,NM-702,NT-702,NM702,INDI702
	Parogrelil is a phosphodiesterase (PDE3/PDE5A) inhibitor potentially for the treatment of intermittent. Parogrelil suppress the asthmatic response in guinea pigs, with both bronchodilating and anti-inflammatory effects. Parogrelil improves reduced walking
T37225	(±)7(8)-DiHDPA
	(±)7(8)-DiHDPA is a major metabolite of docosahexaenoic acid that is produced via oxidation by cytochrome P450 epoxygenases. Epoxygenase metabolites of DHA, including (±)7(8)-DiHDPA, suppress aggregation and thromboxane synthesis in isolated platelets.
T70926	BRN-103
	BRN-103 was found to suppress the VEGF-induced phosphorylation of VEGF receptor 2 (VEGR2) and the activations of AKT and eNOS. Taken together, these results suggest that BRN-103 inhibits VEGF-mediated angiogenesis signaling in human endothelial cells.
T39444	Upacicalcet sodium
	Upacicalcet (sodium) is an intravenous calcimimetic agent that acts directly on parathyroid cell membrane calcium-sensing receptors to suppress excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels. It is indicated for the research of secondary hyperparathyroidism (SHPT).
T69546	MP-135
	MP135 is a Novel μ−δ Opioid Receptor Heteromer-Selective Agonist. MP135 maintains untoward side effects such as respiratory depression and reward behavior; together, these results suggest that optimization of MP135 is necessary for the development of therapeutics that suppress the classical side effects associated with conventional clinical opioids.
T29161	STOCK2S-26016 WNK IN B,WNK-IN-B,Compound B
	WNK-IN-B is an inhibitor of Wnk signalling. WNK-IN-B is a cell-permeable diaminoacridine derivative that targets the CCT domain of SPAK and OSR1 via reversible binding. WNK-IN-B selectively suppress hypotonic shock-induced WNK signaling pathway activation
T36927	Hydrocortisone phosphate
	Hydrocortisone phosphate is the pharmaceutical term for cortisol, which is a steroid hormone, in the glucocorticoid class of hormones, increases blood sugar through gluconeogenesis, to suppress the immune system, and to aid in the metabolism of fat, protein, and carbohydrate.
T61679	Abacavir monosulfate
	Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, and has the ability to penetrate the blood-brain-barrier and suppress telomerase activity [1] [2] [3].
T81625	Obestatin(human) TFA
	Obestatin(human) TFA, 同源于与ghrelin相同的前体多肽，是一种内源性肽。该化合物抑制大鼠食欲并降低体重增加。
T82645	Cyclic PSAP peptide
	Cyclic PSAP peptide（DWLPK）是一种环五肽，具有活性分子特性，在体内能够抑制肿瘤转移扩散和发展。
T73994	Nedosiran sodium
	Nedosiran sodium 是一种靶向乳酸脱氢酶 (LDH)的 RNA 干扰剂 (RNAi)。Nedosiran sodium?可用于研究并发终末期肾病 (ESRD)的原发性高草酸尿症 (PH)。
T78073	HP210	Glucocorticoid Receptor	Endocrinology/Hormones
	HP210是一种选择性糖皮质激素受体调节剂(SGRM)，可以抑制IL-1β和IL-6的mRNA表达，有望用于研究炎症相关疾病。
T68869	TP-110
	TP-110 is a new proteasome inhibitor, which shows potent growth inhibition in various tumor cell lines. Treatment with TP-110 for 24 h in vitro induced apoptosis in multiple myeloma cell line RPMI8226. TP-110 reduced the intrinsic inhibitor of apoptosis proteins (IAPs), cIAP-1 and XIAP, that suppress executioner caspases.
T37216	N-Arachidonoyl-L-Alanine
	Several different arachidonoyl amino acids, including N-arachidonoyl-L-alanine (NALA), have been isolated and characterized from bovine brain. The glycine congener (NAGly) was further characterized and found to suppress formalin-induced pain in rats. NALA may have activity at cannabinoid receptor and/or VR1, but has not been fully characterized to date.
T81243	RXFP1 receptor agonist-4
	RXFP1 receptor agonist-4 (Example 268)为一种特异性RXFP1受体激动剂，其能够抑制HEK293细胞中稳定表达人RXFP1受体的cAMP生成，EC50值达4.9 nM。
T78574	EGFR-IN-85	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-85（Compound 1）为EGFR抑制剂，对EGFRvⅢ磷酸化具有0.19 μM的IC50。本化合物可抑制肿瘤内EGFR信号传导，适用于恶性胶质瘤（GBM）研究。
T69557	ABI-231 HCl
	ABI-231 is a potent, orally bioavailable tubulin inhibitor that interacts with the colchicine binding site and is currently undergoing clinical trials for prostate cancer. ABI-231, has an average IC50 = 5.2 nM against panels of melanoma and prostate cancer cell lines, is orally bioavailable, and strongly suppress melanoma tumors in vivo. ABI-231 holds great promise as a new generation of orally available tubulin inhibitor.
T74550	Cemdisiran, terminal sugar modification-
	Cemdisiran（终端糖基修饰）是一种靶向C5 mRNA的siRNA，通过N-乙酰半乳糖胺缀合增强RNAi活性，能够抑制肝脏中补体成分C5的生成。

化合物

Cat.No: T8575

Target: Platelet aggregation

Immunosuppressant-1

Cat.No: T79791

Target: Apoptosis

Neomyosuppressin

Cat.No: T25862

Synonym: Thr-asp-val-asp-his-val-phe-leu-arg-phenh2,Dromyosuppressin,Neb-MS

p53 tumor suppressor fragment

Cat.No: TP2281

Target: Others

Leucomyosuppressin

Cat.No: T25683

Synonym: p-Glu-asp-val-asp-his-val-phe-leu-arg-phe-NH2

Cat.No: T5403

Target: Autophagy

Fadrozole hydrochloride

Cat.No: T7556

Synonym: CGS 16949A,盐酸法倔唑

Target: Aromatase

JTP 0819958 - HOIPIN-1

Cat.No: T8951

Target: IκB/IKK

Tricaine methanesulfonate

Cat.No: T21483

Synonym: 3-氨基苯甲酸乙酯甲基磺酸盐,MS-222

Target: Others

Cat.No: T11600

Synonym: Isoquinoline

Target: DNA/RNA Synthesis

Cat.No: T21482

Target: P450, ROS Kinase

Cat.No: T8528

Target: TRP/TRPV Channel

Cat.No: T61392

Synonym: ZVN26391

Target: NOD

Cat.No: T9765

Target: MyD88

JMJD6 inhibitor WL12

Cat.No: T9939

Synonym: 2H-1-Benzopyran-2-one, 3-(3H-imidazo[4,5-c]pyridin-2-yl)-6-methyl-,ZINC6733033

Target: Others

Cat.No: T36520

Target: Cannabinoid Receptor, GABA Receptor

Cidofovir dihydrate

Cat.No: T8736

Synonym: HPMPC,(S)-HPMPC,GS 0504,西多福韦二水合物

Target: Others

Cat.No: T4206

Target: TLR

Cat.No: T38273

Synonym: (2R,3R)-Paclobutrazol,多效唑,(R,R)-paclobutrazol,2R,3R-Paclobutrazol

Target: Antifungal

Ulipristal acetate

Cat.No: T2527

Synonym: Ulipristal,醋酸乌利司他,CDB-2914

Target: Estrogen/progestogen Receptor, Progesterone Receptor, Autophagy

Cat.No: T67836

Target: HSP, HSV

Cat.No: T9398

Synonym: NSC 97967

Target: Others

Cat.No: T15096

Synonym: JTE-052,迪高替尼,Corectim（Delgocitinib）

Target: Tyrosine Kinases, JAK

Theophylline monohydrate

Cat.No: T1083L

Synonym: Quibron,茶碱一水合物

Target: HDAC, PDE, Adenosine Receptor

PIN1 inhibitor API-1

Cat.No: T16538

Target: Others

DL-Penicillamine

Cat.No: T0983L

Synonym: 3-Sulfanylvaline,DL-青霉胺

Target: Antibiotic

Cat.No: T30923

Synonym: UNII-05127JZ9KQ

Cat.No: T23706

Synonym: EB382,EB 382,EB-382

Cat.No: T26883

Synonym: BO2367,BO-2367

Cat.No: T23697

Synonym: J1.090.276B,AL8417,(2R)-AL-5898

Cat.No: T68884

Selnoflast calcium

Cat.No: T78613

Synonym: RO-7486967 calcium

Target: NOD-like Receptor (NLR)

Parogrelil hydrochloride

Cat.No: T28296

Synonym: INDI-702,NM-702,NT-702,NM702,INDI702

(±)7(8)-DiHDPA

Cat.No: T37225

Cat.No: T70926

Upacicalcet sodium

Cat.No: T39444

Cat.No: T69546

Cat.No: T29161

Synonym: WNK IN B,WNK-IN-B,Compound B

Hydrocortisone phosphate

Cat.No: T36927

Abacavir monosulfate

Cat.No: T61679

Obestatin(human) TFA

Cat.No: T81625

Cyclic PSAP peptide

Cat.No: T82645

Nedosiran sodium

Cat.No: T73994

Cat.No: T78073

Target: Glucocorticoid Receptor

Cat.No: T68869

N-Arachidonoyl-L-Alanine

Cat.No: T37216

RXFP1 receptor agonist-4

Cat.No: T81243

Cat.No: T78574

Target: EGFR

Cat.No: T69557

Cemdisiran, terminal sugar modification-

Cat.No: T74550

Cat. No.	Product Name	Target	Signaling Pathways
T13522	7-Ketolithocholic acid 3α-Hydroxy-7-oxo-5β-cholanic acid	Endogenous Metabolite	Metabolism
	7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid) (3α-Hydroxy-7-oxo-5β-cholanic acid) is capable of absorption and serves to suppress the production of endogenous bile acid and the secretion of biliary cholesterol.
TN2197	Secoisolariciresinol	TNF	Apoptosis
	Secoisolariciresinol 是一种属于苯丙素类的木脂素。
TN1839	Kumatakenin Jaranol,华良姜素，熊竹素,Kaempferol 3,7-O-dimethyl ether	Apoptosis; Anti-infection	Apoptosis; Microbiology/Virology
	Kumatakenin 是一种从丁香中分离得到的黄酮类天然产物，可诱导卵巢癌细胞凋亡。
T4732	L-Carnosine Karnozin,L-肌肽,beta-Alanyl-L-histidine	Antioxidant; Endogenous Metabolite	Metabolism; oxidation-reduction
	L-Carnosine (Karnozin) 是由beta-丙氨酸和组氨酸组成的二肽，具有抑制衰老的作用。
TN3967	Epieriocalyxin A	ERK; BCL; ROS; Caspase; DNA/RNA Synthesis; JNK	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Proteases/Proteasome
	Epieriocalyxin A 可以抑制 Caco-2 结肠癌细胞的生长。它可能是未来结肠癌治疗的潜在药物。
T3S0335	Soyasaponin Bb Soyasaponin I,大豆皂苷Bb	NF-κB; Caspase	Apoptosis; NF-κB; Proteases/Proteasome
	Soyasaponin Bb (Soyasaponin I) 是一种分离自菜豆科中的大豆皂苷，可用作醛糖还原酶差异抑制剂。
T5802	Stearyl glycyrrhetinate	Antiviral; Antibacterial	Immunology/Inflammation; Microbiology/Virology
	Stearyl glycyrrhetinate 是甘草提取物中的主要成分之一，具有抗菌作用，对金黄色葡萄球菌菌株的 MIC 大于 256 mg/L。
T3869	Skimmin 茵芋苷,Skimmine	Others	Others
	Skimmin (Skimmine) 是一种香豆素类物质。存在于圆锥绣球中，能够抑制免疫复合物的沉积，具有抗炎作用。
TN1334	7-Methoxyrosmanol 7ALPHA-甲氧基迷迭香酚,7-O-Methylrosmanol	cAMP	GPCR/G Protein
	7-Methoxyrosmanol (7-O-Methylrosmanol) 是一种酚类二萜，从迷迭香中分离得到，可抑制 PEPCK 和 G6Pase 启动子的 cAMP 反应。
T5660	Menthone	IL Receptor; TNF; NF-κB; Parasite	Apoptosis; Immunology/Inflammation; Microbiology/Virology; NF-κB
	Menthone 是一种从植物和薄荷油中提取的单萜，是精油的主要挥发性成分，具有抗炎和抗氧化特性。
T2759	Loganin Loganoside,马钱子苷	Apoptosis; NF-κB; BACE; AChR; AChE	Apoptosis; Neuroscience; NF-κB
	Loganin (Loganoside) 是山茱萸中的主要环烯醚萜苷类天然产物，具有抗炎、抗休克的作用。
T21344	1-Deoxynojirimycin hydrochloride Moranoline,去氧野艽霉素盐酸盐,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin	PI3K; Antibacterial; Antibiotic; Glucosidase	Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling
	1-Deoxynojirimycin hydrochloride (Moranoline) 是一种口服有效的 α-葡萄糖苷酶抑制剂，具有降血糖、减肥和抗病毒的作用，可抑制餐后血糖，预防糖尿病。
T3391	Corosolic acid Corsolic acid,2α-Hydroxyursolic acid,科罗索酸,Glucosol,Colosolic acid,Colosic acid	FAK; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Corosolic acid (Colosic acid) 是从大花紫薇中提取的一种天然产物，具有抗肿瘤活性。
TN1046	Murrayone	Others	Others
	Murrayone 是一种提取自M. paniculata 中的含有香豆素的化合物。Murrayone 具有独特的药理特性，可用作防止癌症转移的化学预防剂。
T5814	Aurantiamide TMC-58B,橙黄胡椒酰胺	p38 MAPK; NF-κB	MAPK; NF-κB
	Aurantiamide 是马齿苋的活性成分，具有多种生物活性（如抗氧化、抗血小板、抗炎、抗肿瘤活性等），具有口服活性。
T3876	Loureirin B 龙血素B,龙血素 B	PAI-1; ERK; Potassium Channel; JNK	MAPK; Membrane transporter/Ion channel; Metabolism
	Loureirin B 是从剑叶龙血树中分离到的一种黄酮，是 PAI-1抑制剂，IC50值为 26.10 μM。它抑制 KATP，以及 ERK 和 JNK 的磷酸化，具有抗糖尿病的功效。
TN2091	Polygalacin D	Apoptosis; IAP	Apoptosis
	Polygalacin D 是从桔梗中分离的一种天然产物，具有抗癌和抗增殖特性。它通过 PI3K/Akt 途径诱导凋亡。它抑制 IAP 蛋白家族的表达，并通过抑制 GSK3β，Akt 的磷酸化和 PI3K 的表达来阻断 PI3K/Akt 途径。
TN1011	Rhodionin	P450; AChE	Metabolism; Neuroscience
	Rhodionin 是从红景天的根中分离的特异性非竞争性细胞色素 P450 2D6 抑制剂，IC50=0.761 μM，Ki=0.769 μM。它有 DPPH 自由基清除活性，IC50为 19.49 μM。它抑制乙酰胆碱酯酶，IC50范围为 57.50 至 2.43 μg/mL。
T2897	(Rac)-Shikonin (±)-Shikonin,Alkanet extract,Anchusin,紫草素,Anchusa acid	Others	Others
	(Rac)-Shikonin (Anchusin) 具有抗肿瘤作用。它能够诱导坏死死亡来绕过癌症耐药性。
T4958	(-)-Alkannin Alkannin,左旋紫草素,紫草素,Shikonin	Apoptosis; PI3K	Apoptosis; PI3K/Akt/mTOR signaling
	(-)-Alkannin (Shikonin) 是从紫朱草中发现的一种天然产物，具有抗癌活性，可抑制细胞周期，诱导细胞凋亡，用作食品着色剂，在 Rho 激酶途径中可改善肝脏炎症。
T3877	Esculentoside A	NF-κB; COX	Immunology/Inflammation; Neuroscience; NF-κB
	Esculentoside A 是一种三萜皂苷，从商陆根部分离得到。它在具有抗炎活性，对环氧合酶-2 具有选择性抑制活性。它通过抑制NF-κB 和丝裂原活化蛋白激酶信号通路抑制 LPS 诱导的急性肺损伤中的炎症反应。
T6S1784	Brazilin Natural Red 24,巴西苏木素;苏枋精,Braziletto,Brasilin,Superbresiline,巴西苏木素	Apoptosis; Others; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	Brazilin (Braziletto) 是来自几种热带硬木的心材的一种红色染料前体，有软骨保护和抗炎活性。它抑制细胞增殖，促进细胞凋亡并通过 AMPK/mTOR 途径诱导自噬。
TMS1461	Qingyangshengenin B 青阳参甙元B,青阳参苷元B,Otophylloside B	Beta Amyloid	Neuroscience
	Qingyangshengenin B (Otophylloside B) 是一种分离自 Qingyangshen 的 C-21 甾体苷。它能够在 mRNA 水平上抑制 Aβ 的表达来减少 Aβ 的沉积，对 Aβ 的毒性有保护作用。它具有抗癫痫作用。
T5S2357	Acetylcorynoline (+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵	Antifungal	Microbiology/Virology
	Acetylcorynoline (O-Acetylcorynoline) 是提取自 Corydalis bungeana 中的一种主要生物碱成分，具有抗炎活性。
TN2601	12-O-Methylcarnosic acid	Reductase	Endocrinology/Hormones; Metabolism
	12-O-Methylcarnosic acid 是分离自小叶丹参的丙酮提取物的一种二萜肉桂酸，可抑制 5α-还原酶 (5α-reductase) 活性，IC50为 61.7 μM。它抑制 LNCaP 细胞的增殖。它具有抗微生物活性、抗氧化和抗癌活性。
T6429	Caffeic Acid Phenethyl Ester Phenylethyl Caffeate,咖啡酸苯乙酯,CAPE	Apoptosis; NF-κB	Apoptosis; NF-κB
	Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) 是咖啡酸的苯乙醇酯，是蜂巢蜂胶的生物活性成分。它抑制核转录因子 NF-kappa B 的激活，具有抗肿瘤、细胞保护和免疫调节活性。它抑制 PDGF 诱导的血管平滑肌细胞增殖。
T6S1699	Shogaol [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol	Lipoxygenase; Autophagy	Autophagy; Metabolism
	6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物，具有抗癌、抗炎和抗氧化的多种生物活性。
TN3899	Drupacine	Others	Others
	Drupacine and a crude alkaloid extract suppress nematode hatch, activity of mixed life stages, and population numbers on plant roots.
T20604	Litorin
	Litorin, an amphibian bombesin peptide derivative, is found to suppress the nutriment, to stimulate the contraction of smooth muscle, to stimulate gastrin, gastric acid, and pancreatic secretion.
TN4552	Methyl p-hydroxyphenyllactate	Others	Others
	Methyl para-hydroxyphenyllactate(MeHPLA) can suppress the cellular proliferation of estrogen-sensitive MCF-7 breast cancer cells in vitro and to suppress the growth of rat uteri in vivo, high affinity of MeHPLA for the type II estrogen binding site (EBS)
TN4722	Otophylloside F	Others	Others
	Otophylloside F can suppress the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish.
TN5681	Cypellocarpin C Camaldulenside,桉叶苷
	Cypellocarpin C shows potent in vitro antitumor-promoting activity, it also can suppress an in vivo two-stage carcinogenesis induced with nitric oxide and TPA on mouse skin.
T3490	alpha-(3,4-Dihydroxyphenyl)lactic acid	Antioxidant	oxidation-reduction
	alpha-(3,4-Dihydroxyphenyl)lactic acid 具有抗氧化活性，可通过 PI3K/Akt/Nrf2 信号通路增强 HO-1 表达以抑制 6-OHDA 诱导的氧化损伤。
TN4909	(+)-Rhododendrol	Others	Others
	(+)-Rhododendrol shows anti-inflammatory effects, it can suppress the NO production by activated macrophages in vivo.
T3S0541	Curzerene 莪术烯,莪术呋喃烯	Apoptosis; GST	Apoptosis; oxidation-reduction
	Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cancer properties. It is known to induce apoptosis in cells[1] and also suppress the expression of glutathione S-transferase A1 (GSTA1) mRNA and protein.
TN2417	Furomollugin 5-羟基萘并[1,2-B]呋喃-4-甲酸甲酯,呋喃大叶茜草素	Antifection	Microbiology/Virology
	Furomollugin has antiviral activity, it can strongly suppress the secretion of hepatitis B surface antigen (HBsAg), with IC50 = 2.0 micrograms/mL, in human hepatoma Hep3B cells.
TN2134	Raddeanoside 20	Others	Others
	Raddeanoside 20 can slightly suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) in a concentration dependent manner.
TN4387	Khellactone	Antifection	Microbiology/Virology
	Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -sensitive strains of with IC(50) values from 1.5 and 2.4 microM.
TN2507	1,6,7-Trihydroxyxanthone	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell growth and induce apoptosis in liver cancer cells.
TN3691	Communic acid	MMP; MAPK; Akt; PI3K; DNA/RNA Synthesis; Antifection	Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic ingredients, as they suppress UVB-induced MMP-1 expression.
TN4392	Koaburaside	IL Receptor; TNF; Influenza Virus	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic inflammatory activity, it can suppress histamine release from mast cells.
TN5105	Taxagifine	Others	Others
	Taxagifine shows cytotoxic activity toward HepG2 cells; it can suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a concentration-dependent manner.
TN1212	2-Hydroxyeupatolide	Others; TNF; NF-κB	Apoptosis; NF-κB; Others
	2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and make a contribution to further understanding the pharmaceutical activity of Eupatorium plants.
TN3541	Broussonin E	ERK; p38 MAPK; TNF; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells
	Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway, and can be further developed as a promising drug for the treatment of inflammation-related
TN5104	Taxacin	Others	Others
	Taxacin shows strong inhibitory effects on platelet aggregation induced by arachidonic acid (IC(50):21.9 microM). Taxacin can suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a conce
TN4819	(-)-Praeruptorin A	ATPase; IL Receptor; Calcium Channel; P-gp	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis;it also can significantly suppress airway inflammation and airway remodeling induced by ovalbumin challenge, and is a potential candidate for the treatment of asthma. (-)-Praeruptorin A resensitizes Pgp-mediated MDR (Pgp-MDR) cancer cells to cancer drugs.
TN5248	Voleneol	NOS; COX; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependently suppress the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenas
TN5238	Viscidulin II	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β production in THP-1 cells, concomitant intradermal injection of viscidulin II with P. acnes can effectively attenuate P. acnes-induced ear swelling, and decrease the production of IL-6 and tumor necrosis factor-α in ear homogenates.
TN5050	Sprengerinin C	NADPH-oxidase; VEGFR; p38 MAPK; ROS; Akt; PI3K; mTOR; p53	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein endothelial cells, it blocks vascul
TN5880	Mesuol
	Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. Mesuol can suppress HIV-1 replication in Jurkat T cells, it inhibits TNFα-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-κB (NF-κB) pathway.
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天然产物

7-Ketolithocholic acid

Cat.No: T13522

Synonym: 3α-Hydroxy-7-oxo-5β-cholanic acid

Target: Endogenous Metabolite

Secoisolariciresinol

Cat.No: TN2197

Target: TNF

Cat.No: TN1839

Synonym: Jaranol,华良姜素，熊竹素,Kaempferol 3,7-O-dimethyl ether

Target: Apoptosis, Anti-infection

Cat.No: T4732

Synonym: Karnozin,L-肌肽,beta-Alanyl-L-histidine

Target: Antioxidant, Endogenous Metabolite

Epieriocalyxin A

Cat.No: TN3967

Target: ERK, BCL, ROS, Caspase, DNA/RNA Synthesis, JNK

Cat.No: T3S0335

Synonym: Soyasaponin I,大豆皂苷Bb

Target: NF-κB, Caspase

Stearyl glycyrrhetinate

Cat.No: T5802

Target: Antiviral, Antibacterial

Cat.No: T3869

Synonym: 茵芋苷,Skimmine

Target: Others

7-Methoxyrosmanol

Cat.No: TN1334

Synonym: 7ALPHA-甲氧基迷迭香酚,7-O-Methylrosmanol

Target: cAMP

Cat.No: T5660

Target: IL Receptor, TNF, NF-κB, Parasite

Cat.No: T2759

Synonym: Loganoside,马钱子苷

Target: Apoptosis, NF-κB, BACE, AChR, AChE

1-Deoxynojirimycin hydrochloride

Cat.No: T21344

Synonym: Moranoline,去氧野艽霉素盐酸盐,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin

Target: PI3K, Antibacterial, Antibiotic, Glucosidase

Cat.No: T3391

Synonym: Corsolic acid,2α-Hydroxyursolic acid,科罗索酸,Glucosol,Colosolic acid,Colosic acid

Target: FAK, Autophagy

Cat.No: TN1046

Target: Others

Cat.No: T5814

Synonym: TMC-58B,橙黄胡椒酰胺

Target: p38 MAPK, NF-κB

Cat.No: T3876

Synonym: 龙血素B,龙血素 B

Target: PAI-1, ERK, Potassium Channel, JNK

Cat.No: TN2091

Target: Apoptosis, IAP

Cat.No: TN1011

Target: P450, AChE

Cat.No: T2897

Synonym: (±)-Shikonin,Alkanet extract,Anchusin,紫草素,Anchusa acid

Target: Others

Cat.No: T4958

Synonym: Alkannin,左旋紫草素,紫草素,Shikonin

Target: Apoptosis, PI3K

Esculentoside A

Cat.No: T3877

Target: NF-κB, COX

Cat.No: T6S1784

Synonym: Natural Red 24,巴西苏木素;苏枋精,Braziletto,Brasilin,Superbresiline,巴西苏木素

Target: Apoptosis, Others, AMPK, Autophagy

Qingyangshengenin B

Cat.No: TMS1461

Synonym: 青阳参甙元B,青阳参苷元B,Otophylloside B

Target: Beta Amyloid

Acetylcorynoline

Cat.No: T5S2357

Synonym: (+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵

Target: Antifungal

12-O-Methylcarnosic acid

Cat.No: TN2601

Target: Reductase

Caffeic Acid Phenethyl Ester

Cat.No: T6429

Synonym: Phenylethyl Caffeate,咖啡酸苯乙酯,CAPE

Target: Apoptosis, NF-κB

Cat.No: T6S1699

Synonym: [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol

Target: Lipoxygenase, Autophagy

Cat.No: TN3899

Target: Others

Cat.No: T20604

Methyl p-hydroxyphenyllactate

Cat.No: TN4552

Target: Others

Otophylloside F

Cat.No: TN4722

Target: Others

Cypellocarpin C

Cat.No: TN5681

Synonym: Camaldulenside,桉叶苷

alpha-(3,4-Dihydroxyphenyl)lactic acid

Cat.No: T3490

Target: Antioxidant

(+)-Rhododendrol

Cat.No: TN4909

Target: Others

Cat.No: T3S0541

Synonym: 莪术烯,莪术呋喃烯

Target: Apoptosis, GST

Cat.No: TN2417

Synonym: 5-羟基萘并[1,2-B]呋喃-4-甲酸甲酯,呋喃大叶茜草素

Target: Antifection

Raddeanoside 20

Cat.No: TN2134

Target: Others

Cat.No: TN4387

Target: Antifection

1,6,7-Trihydroxyxanthone

Cat.No: TN2507

Target: DNA/RNA Synthesis

Cat.No: TN3691

Target: MMP, MAPK, Akt, PI3K, DNA/RNA Synthesis, Antifection

Cat.No: TN4392

Target: IL Receptor, TNF, Influenza Virus

Cat.No: TN5105

Target: Others

2-Hydroxyeupatolide

Cat.No: TN1212

Target: Others, TNF, NF-κB

Cat.No: TN3541

Target: ERK, p38 MAPK, TNF, JAK, STAT

Cat.No: TN5104

Target: Others

(-)-Praeruptorin A

Cat.No: TN4819

Target: ATPase, IL Receptor, Calcium Channel, P-gp

Cat.No: TN5248

Target: NOS, COX, Prostaglandin Receptor

Cat.No: TN5238

Target: IL Receptor, TNF

Cat.No: TN5050

Target: NADPH-oxidase, VEGFR, p38 MAPK, ROS, Akt, PI3K, mTOR, p53

Cat.No: TN5880

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