streptomyces a-factor

Streptomyces A-Factor is a microbial hormone found in Streptomyces griseus. A-factor triggers streptomycin biosynthesis and cell differentiation by binding a repressor-type receptor protein (ArpA) and dissociating it from DNA.

Echinomycin (Quinomycin A) 是一种从链霉菌中分离出的抗肿瘤抗生素次级代谢物，是一种喹喔啉类抗生素，是一种 DNA 双嵌入肽，抑制低氧诱导因子-1 (HIF-1) DNA 结合活性。Echinomycin 具有潜在是抗癌活性，可用于研究三阴性乳腺癌。

Leustroducsin B is a novel colony-stimulating factor (CSF) inducer extracted from Streptomyces platensis SANK 60191.

Herboxidiene (GEX1A) 是一种可从染色链霉菌 ATCC 49982 中分离出来的植物毒性聚酮类化合物，具有除草、抗胆固醇和抗肿瘤活性，通过下调血管内皮生长因子受体-2 和缺氧诱导因子-1α 显示出抗血管生成活性。

Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb MK cells (IC50 = 0.7 μg ml), displays antiproliferative activity against human KB and K562 tumor cell lines (IC50s = 1.9 and 1.6 μg ml, respectively), and demonstrates antifungal activity against C. albicans (MIC = 2 μg ml at pH 3). Reveromycin A also has been shown to inhibit bone resorption by inducing apoptosis in osteoclasts with an IC50 value of 0.7 μM.

FR 900452 is a platelet activating factor antagonist from fermentatiion products of Streptomyces phaeofaciens.