spdb-sulfo

SPDB-sulfo, a glutathione-cleavable linker, is utilized in the development of antibody-drug conjugates (ADCs) [1].

NO2-SPDB-sulfo is a cleavable linker vital in ADC synthesis. NO2-SPDB-sulfo joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

DMAC-SPDB-sulfo is a cleavable linker vital in ADC synthesis. DMAC-SPDB-sulfo joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Sulfo-SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs) that employs the maytansine-based payload (DM4, an antitubulin agent) connected through the sulfo-SPDB linker.

sulfo-SPDB is a cleavable linker vital in ADC synthesis. sulfo-SPDB joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Sulfo-SPDB (GMP)是 Sulfo-SPDB 的 GMP 级别试剂。Sulfo-SPDB 是一种在抗体药物偶联物（ADC）合成过程中不可或缺的可裂解连接剂。Sulfo-SPDB 将细胞毒性药物与抗体连接在一起，能够实现对细胞或蛋白质的精准递送。其可裂解的特性确保了药物的可控释放，从而优化了 ADC 的效果。

Sulfo-SPDB-DGN462为一种ADC活性连接剂，毒素DGN462通过可裂解的Sulfo-SPDB linker偶联形成。DGN462是一种DNA烷基化剂，对抗肿瘤（如急性髓系白血病[AML]）表现出有效性。