spdb

SPDB 是一种可降解的 ADC 连接剂，可用于合成抗体偶联药物。SPDB是一个与 DM4 偶联物相连的小片段并利用二硫键与抗体偶联。

SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, employing the maytansine-based payload DM4 (a tubulin inhibitor) connected through a SPDB linker. This compound demonstrates significant anti-tumor efficacy.

SPDB-sulfo, a glutathione-cleavable linker, is utilized in the development of antibody-drug conjugates (ADCs) [1].

Sulfo-SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs) that employs the maytansine-based payload (DM4, an antitubulin agent) connected through the sulfo-SPDB linker.

sulfo-SPDB is a cleavable linker vital in ADC synthesis. sulfo-SPDB joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Sulfo-SPDB (GMP)是 Sulfo-SPDB 的 GMP 级别试剂。Sulfo-SPDB 是一种在抗体药物偶联物（ADC）合成过程中不可或缺的可裂解连接剂。Sulfo-SPDB 将细胞毒性药物与抗体连接在一起，能够实现对细胞或蛋白质的精准递送。其可裂解的特性确保了药物的可控释放，从而优化了 ADC 的效果。

SPDB-DM4 是 ADC 的一部分，由 DM1 (一种微管蛋白抑制剂，也是一种抗体可缀合的美登木素生物碱，用于克服与美登素相关的全身毒性并增强肿瘤特异性递送) 和 SPDB 连接而成，具有高效的抗肿瘤活性。

Lys-Nε-SPDB-DM4 is a drug-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Lys-Nε-SPDB to make antibody drug conjugate (ADC).

NO2-SPDB-sulfo is a cleavable linker vital in ADC synthesis. NO2-SPDB-sulfo joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

DMAC-SPDB is a cleavable linker vital in ADC synthesis. DMAC-SPDB joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

DMAC-SPDB-sulfo is a cleavable linker vital in ADC synthesis. DMAC-SPDB-sulfo joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Sulfo-SPDB-DGN462为一种ADC活性连接剂，毒素DGN462通过可裂解的Sulfo-SPDB linker偶联形成。DGN462是一种DNA烷基化剂，对抗肿瘤（如急性髓系白血病[AML]）表现出有效性。

Dimethylamine-SPDB是一种可降解 (cleavable) 的ADC linker，用于合成抗体偶联活性分子 (ADC)。

Tusamitamab ravtansine (SAR-408701) 是一款针对CEACAM5的人源化单克隆抗体与DM4细胞毒性药物经活性分子连接而成的抗体-药物偶联物(ADC)，专门靶向CEACAM5表达的肿瘤细胞。