seco-duba

Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs).

Seco-DUBA hydrochloride is a toxin for ADC drug SYD985.

Vc-seco-DUBA is a drug-linker conjugate for ADC with potent antitumor activity by using DUBA (DNA alkylating agent), linked via the ADC linker Vc-seco[1].

Desmethyl Vc-seco-DUBA 是由可降解的ADC linker（Desmethyl Vc-seco）和DNA烷化剂DUBA构成，适用于ADC的合成。

Vobramitamab为针对人源B7-H3的单克隆抗体(mAb)。该抗体通过一个可切割的连接物与前药seco-DUBA相结合，构成一种抗体-药物偶联物(ADC)名为MGC018。