sdh 2

SDH-IN-2 是一种有效的琥珀酸脱氢酶 (SDH) 抑制剂，IC50 为 0.55 μg mL。SDH-IN-2 具有抗真菌活性，抑制植物病原真菌的平均 EC50 值为 3.82-9.81 μg mL

Succinate dehydrogenase-IN-2 (Compound 12x) 作为一种琥珀酸脱氢酶 (succinate dehydrogenase,SDH) 的抑制剂,表现出IC50值为1.22 mg L.此化合物还展示了对多种真菌的抗性,包括S. sclerotiorum、V. mali、G. graminis、R. solani和B. cinerea,其EC50范围为0.52-3.42 mg L,表明其在抑制这些真菌方面的有效性.

Sitamaquine is an antileishmanial agent.1It is active againstL. donovani,L. infantum,L. mexicana,L. braziliensis, andL. tropica(EC50s = 9.5-19.8 μM). It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH), in a cell-free assay when used at concentrations ranging from 10 to 200 μM.2Sitamaquine (100 μM) increases intracellular levels of reactive oxygen species (ROS) and decreases intracellular ATP levels, as well as induces phosphatidylserine externalization, chromatin fragmentation, and depolarization of the mitochondrial membrane potential, markers of apoptosis, inL. donovanipromastigotes. 1.López-Martín, C., Pérez-Victoria, J.M., Carvalho, L., et al.Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomesAntimicrob. Agents Chemother.52(11)4030-4036(2008) 2.Carvalho, L.J.M., Luque-Ortega, J.R., López-Martín, C., et al.The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenaseAntimicrob. Agents Chemother.55(9)4204-4210(2011)