qx314

QX 314 (Lidocaine N-ethyl bromide) 是一种非膜渗透性阻滞剂，可抑制酸诱导的食管伤害性 C 纤维神经元活化。

QX-314 chloride 是钠离子通道电荷阻滞剂，具有膜不渗透性。

Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported. CAY10568 is a physically smaller, less hydrophobic version of QX314 designed to be even more permeable to TRPV1 ion channel when activated by agonists such as capsaicin and N-oleoyl dopamine. CAY10568 when given in combination with suitable TRPV1 agonists should produce selective blockade of the pain response while leaving motor, touch, and proprioception intact.