购物车
  • 全部删除
  • TargetMol
    您的购物车当前为空
筛选
已筛选:全部清除
TargetMol | Tags 通过 靶点 筛选
  • Others
    (1)
TargetMol | Tags 通过 货期 筛选
  • 35日内发货
    (1)
抑制剂&激动剂
细分筛选
搜索结果
TargetMol产品目录中 "pyrrophenone"的结果
筛选
搜索结果
TargetMol产品目录中 "

pyrrophenone

"的结果
  • 抑制剂&激动剂
    1
    TargetMol | Inhibitors_Agonists
  • Pyrrophenone
    T37331341973-06-6
    The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid (AA) from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins (PGs) and leukotrienes (LTs). Pyrrophenone inhibits cPLA2α with an IC50 of 4.2 nM in enzyme assays and potently blocks the release of AA and the production of PGE2 and LTC4 in cells (IC50 = 24, 25, and 14 nM, respectively). Its action is reversible and selective, as pyrrophenone inhibits the secretory type IB and IIA PLA2s with more than a hundred-fold less potency. Pyrrophenone has also been shown to inhibit calcium ionophore (A23187)-stimulated AA release from monocytic cells, interleukin-1-induced PGE2 synthesis in mesangial cells, and the production of PGE2, LTs, and platelet-activating factor by human neutrophils, always with maximal inhibition at concentrations below 1 μM.
    • 待估
    35日内发货
    规格
    数量