protac rar degrader-1

PROTAC RAR Degrader-1 comprises a cIAP1 ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].

Bestatin-amide-PEG3-CH2-acid 是一种 E3 泛素酶配体-连接子偶联物 (E3 Ligase Ligand-linker conjugate)，可用于合成PROTAC RAR Degrader-1。