Thiophene-2 (TP2) is a targeted inhibitor of polyketidesynthase13 (Pks13), specifically designed to disrupt mycolic acid biosynthesis. By doing so, it effectively induces rapid cell death in mycobacteria. Thiophene-2 demonstrates notable anti-tuberculosis activity and exhibits a minimum inhibitory concentration (MIC) value of 1 μM against Mycobacterium tuberculosis.
Polyketidesynthase13-IN-2 (comp 42) is a potent inhibitor of polyketidesynthase13in Mycobacterium tuberculosis. It demonstrates a minimum inhibitory concentration (MIC) of 0.25 μg mL [1].