piperazine derivative

Cinepazide maleate (MD-67350) 是哌嗪衍生物，是一种钙通道阻滞剂，也是一种强效血管扩张剂，可用于脑血管疾病的研究，如缺血性中风和脑梗塞等。

CGP 29030A 是一种新的哌嗪衍生物，具有镇痛活性，对潜在的痛觉背角神经元有显著的抑制作用，可用于研究疼痛性疾病。

Piperazine,1-(4-fluorophenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-是一种哌嗪衍生物，显示出抗 SARS-CoV-2活性。

Prasugrel (CS-747) 是一种噻吩吡啶和前药，是一种可口服的 P2Y12受体拮抗剂，抑制 ADP 诱导的血小板聚集，用于预防急性冠状动脉综合征患者的血栓形成、不稳定型心绞痛和心肌梗塞，以及接受经皮冠状动脉介入治疗的患者。

Cinnarizine (Stugeron) 是一种哌嗪衍生物，具有组胺 H1 受体和钙通道阻断活性，具有扩张血管和止吐的特性，可促进脑血流，用于脑中风、创伤后脑症状和脑动脉硬化的研究。

Prazosin hydrochloride (Vasoflex) 是一种选择性肾上腺素能 α-1 拮抗剂，可降低外周阻力并放松血管平滑肌。 它可用于研究高血压和酒精使用障碍。 它是一种合成哌嗪衍生物，具有降压抗肾上腺素能特性。它抑制有机阳离子转运蛋白 OCT-1 和 OCT-3，IC50分别为 1.8 和 13 μM 。

Prasugrel Hydrochloride (LY 640315 Hydrochloride) 是一种噻吩吡啶和前药，是一种可口服的P2Y12受体拮抗剂，抑制 ADP 诱导的血小板聚集，用于预防急性冠状动脉综合征患者的血栓形成、不稳定型心绞痛和心肌梗塞，以及接受经皮冠状动脉介入治疗的患者。

1-(1-phenyltetrazol-5-yl)piperazine;hydrochloride (1-(1-phenyl-1H-1,2,3,4-tetrazol-5-yl)piperazine hydrochloride) 是一种哌嗪的化学衍生物，已被用作合成其他化合物的起始材料，如抗炎剂。它通过与酶和蛋白质的活性位点结合来调节其活性，已被用于酶抑制和蛋白质结构的研究，以及药物代谢的研究。

GBR-12935 is a piperazine derivative. It is an effective and selective dopamine reuptake inhibitor. GBR-12935 is now widely used in animal research into Parkinson's disease and the dopamine pathways in the brain.

1-(4-Methoxyphenyl)piperazine (Piperazine, 1-(4-methoxyphenyl)-) hydrochloride 是一种具有精神活性的哌嗪衍生物。

[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methanamine 是一种哌嗪衍生物，它是血清素和多巴胺受体的部分激动剂，使其成为治疗抑郁症和精神分裂症等精神疾病的候选药物。

Cinnarizine clofibrate is a calcium channel protein inhibitor as well as an antihistamine channel blocker. The compound is a drug derivative of piperazine. Cinnarizine is used for the control of vomiting due to motion sickness. It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus

Acefylline piperazine is a stimulant drug of the xanthine chemical class. It acts as an adenosine receptor antagonist. Acephylline piperazine is a theophylline derivative with a direct bronchodilator action. It has the advantages over theophylline in being far less toxic and producing minimal gastric irritation. It is indicated for the treatment of asthma, emphysema, acute and chronic bronchitis associated with bronchospasm.Acefylline relaxes smooth muscles, relieves bronchospasm & has a stimulant effect on respiration. It stimulates the myocardium & central nervous system, decreases peripheral resistance & venous pressure & causes diuresis. The mechanism of action is still not clear, inhibition of phosphodiesterase with a resulting increase in intracellular cyclic AMP does occur, but not apparently at concentrations normally used for clinical effect. Other proposed mechanisms of action include adenosine receptor antagonism, prostaglandin antagonism & effects on intracellular......

Thalidomide-Piperazine 5-fluoride hydrochloride，作为Thalidomide衍生物，是一种cereblon(CRBN)抑制剂，用作E3 泛素连接酶的配体(Ligands for E3 Ligase)，适用于PROTACs合成。