npr2

CCW 28-3 is a novel potent covalent BRD4 degrader, degrading BRD4 in a proteasome- and RNF4-dependent manner without inhibiting RNF4 autoubiquitination activity.

Vosoritide (BMN 111) acetate，一种NPR2（利尿钠肽受体2）激动剂，作用于软骨细胞增殖与分化，促进骨骼生长。