mifepristone

Mifepristone (C-1073) 是一种黄体酮受体和糖皮质激素受体拮抗剂，在体外实验中的 IC50值分别为 0.2 nM 和 2.6 nM。

22-Hydroxy Mifepristone (RU 42698) 是一种口服活性的羟基化酒精代谢物，展现出抗孕激素与抗糖皮质激素的生物活性。该化合物中包含炔烃基团，能够参与含叠氮基团分子的铜催化的叠氮-炔烃环加成反应 (CuAAc)。此外，22-Hydroxy Mifepristone 对人类糖皮质激素受体 (glucocorticoid receptor) 显示出48%的结合亲和力。

Mifepristone methochloride is a glucocorticoid antagonist. This product will be sold for research use only.

N-Demethyl Mifepristone (RU 42633) 为一种Mifepristone的活性代谢产物，其对糖皮质激素受体 (glucocorticoid receptor) 的亲和力相对于Mifepristone (100%) 为61%。

Mifepristone-d6 是 Mifepristone 的氘代化合物。Mifepristone 的 CAS 号为 84371-65-3。Mifepristone 是一种黄体酮受体和糖皮质激素受体拮抗剂，在体外实验中的IC50值分别为 0.2 nM 和 2.6 nM。

Gemeprost, an analog of prostaglandin E1, is used for the treatment of obstetric bleeding. It is used to terminate pregnancy up to 24 weeks gestation together with mifepristone.

Aglepristone is a synthetic steroidal antiprogestogen related to mifepristone and possesses some antiglucocorticoid activity. It is specifically used as an abortifacient in pregnant animals.

Lonaprisan is an orally bioavailable pentafluoroethyl derivative of a mifepristone-related steroid with antiprogestagenic activity. Lonaprisan is a pure, highly receptor-selective progesterone receptor (PR) antagonist; binding of this agent to PRs inhibits PR activation and the associated proliferative effects. Unlike many other antiprogestins such as mifepristone, this agent does not appear to convert to an agonist in the presence of protein kinase A (PKA) activators and shows high antiprogestagenic activity on both progesterone receptor (PR) isoforms PR-A and PR-B.