m-31

YM-31636 (free base) 为具口服活性的高效选择性5-HT3受体激动剂，其pKi为9.67。该化合物可引起离体豚鼠远端结肠收缩，并在离体豚鼠右心房中诱导心动过速，拥有约0.23的相对内在活性。YM-31636 (free base) 有潜力应用于便秘研究领域。

SAM-315 (WAY-255315) 是一种对5-羟色胺-6 (5-Hydroxytryptamine-6) 具有高效拮抗作用的化合物，其Ki为1.1 nM，IC50为4.6 nM。SAM-315 能显著提高大脑海马区域乙酰胆碱和谷氨酸的释放量。

AM-3102 is an OEA analog that stimulates PPARα transcriptional activity and prolongs feeding latency. It is resistant to enzymatic hydrolysis and is as potent as OEA in enhancing transcriptional activity of PPARα and reducing food intake in free-feeding r

AM-3189 is a potent and selective GPR40 Agonist with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837. AM-3189 maintains the in vivo efficacy of AMG 837 while displaying a superior pharmacokinetic profile and minimal CNS exposure. Similar to AMG 837, while highly potent on GPR40, AM-3189 was highly selective over the closely related GPCRs, GPR41 and GPR43. 13kdemonstrated low clearance, moderate volume of distribution, and good oral bioavailability. AM-3189 does not penetrate the rat CNS as indicated by a rat brain to plasma ratio of 0.04 at 3 h after an oral dose of 5 mg kg.

M-31850 (1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-) 是一种竞争性的 β-己糖胺酶选择性抑制剂，能够抑制人HexA (IC50:6.0 µM) 及HexB (IC50:3.1 µM)。它还能够竞争性抑制 β-N-acetyl-D-hexosaminidaseOfHex2 (Ki:2.5 µM)。

NGM-313 是一种由 CHO 细胞表达的人源抗体，专门靶向 Klotho Beta。NGM-313 带有 huIgG1 型重链和 huκ 型轻链，预测分子量 (MW) 为 150 kDa。NGM-313 的同型对照可参阅 HumanIgG1kappa，Isotype Control。

LDN193189 (DM-3189) 是一种 BMP I 型受体的选择性抑制剂，可以抑制 ALK2 和 ALK3 (IC50=5 30 nM)，对 ALK4、ALK5 和 ALK7 的活性较弱。LDN193189 可以用于进行性骨化性纤维发育不良的研究。

Plerixafor (AMD-3329) 是一种趋化因子受体拮抗剂，可阻断基质细胞衍生因子与细胞受体 CXCR4 的结合。它也是 CXCR7 的变构激动剂，是免疫刺激剂和造血干细胞动员剂，还抑制HIV-1和HIV-2的复制，EC50为 1-10 nM。

Plerixafor octahydrochloride (JM3100 octahydrochloride) 是一种选择性的CXCR4拮抗剂，IC50为 44 nM。Plerixafor 是一种具有造血干细胞动员活性的双环霉素。

Palmitoylethanolamide (Impulsin) 是一种内源性脂肪酸酰胺。它有消炎药、降压药、神经保护剂和抗惊厥药的作用。在给药后，Palmitoylethanolamide 可抑制促炎介质从活化肥大细胞的释放。

BDM31343是一种结核分枝杆菌中EthR抑制剂，可增以纳摩尔效力增强乙硫异烟胺的抗菌活性，同时提高溶解度和代谢稳定性。

QM31 is a selective Apaf-1 inhibitor(inbitita formation of the apoptosome with IC50 of 7.9μM).

Depiperazine-DM3189对Bone morphogenetic protein 4诱导的SMAD 1 5 8磷酸化具有抑制活性，可用于生化实验和药物合成。

BDM31827 is an EthR inhibitor.

FG-2216 (YM-311) 是一种有效的、口服具有活力的HIF 脯氨酰羟化酶-2 (PHD2) 抑制剂，IC50=3.9 nM。它在体内能够诱导促红细胞生成素生成和胎儿血红蛋白的表达。

LDN-193189 2HCl (DM-3189 2HCl) 是一种选择性 BMP 信号抑制剂，对ALK1,ALK2,ALK3和ALK6有抑制作用，在激酶实验中显示的 IC50 分别为 0.8 nM、0.8 nM、5.3 nM 和 16.7 nM。LDN-193189 2HCl 在C2C12细胞中对BMP I 型受体ALK2和ALK3的转录活性有抑制作用，IC50分别为5 nM 和30 nM，作用于BMP 比作用于TGF-β选择性高200倍。

MM3122 (MM-3122) 是一种选择性的 II 型跨膜丝氨酸蛋白酶 (TMPRSS2) 抑制剂，IC50为 0.34 nM。MM3122 可以有效阻断 TMPRSS2，从而抑制 SARS-CoV-2 和 MERS-CoV 进入人类细胞。

Rustmicin is a 14-membered macrolide identified as an inhibitor of plant pathogenic fungi.

CK37 controls the biological activity of Choline Kinase-α. This small molecule inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

BDM31369 is an activator of ethionamide.

Stapokibart (CM310) 是一种靶向 IL-4Rα 的人源化单克隆抗体，阻断 IL-4Rα 介导的信号传导，可用于研究特应性皮炎。

AR-M 1896 Acetate 是 GalR2 的选择性激动剂。

β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius.2β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 μg/ml, respectively. β-Defensin-2 induces IL-31 production by human peripheral blood-derived mast cellsin vitrowhen used at a concentration of 10 μg/ml and by rat mast cellsin vivofollowing a 500 ng intradermal dose.4Expression of β-defensin-2 is increased in psoriatic skin and chronic wounds.5,6 1.Lehrer, R.I.Primate defensinsNat. Rev. Microbiol.2(9)727-738(2004) 2.Ouhara, K., Komatsuzawa, H., Yamada, S., et al.Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, β-defensins and LL37, produced by human epithelial cellsJ. Antimicrob. Chemother.55(6)888-896(2005) 3.Niyonsaba, F., Ushio, H., Nakano, N., et al.Antimicrobial peptides human β-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokinesJ. Invest. Dermatol.127(3)594-604(2007) 4.Niyonsaba, F., Ushio, H., Hara, M., et al.Antimicrobial peptides human β-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cellsJ. Immunol.184(7)3526-3534(2010) 5.Huh, W.-K., Oono, T., Shirafuji, Y., et al.Dynamic alteration of human β-defensin 2 localization from cytoplasm to intercellular space in psoriatic skinJ. Mol. Med. (Berl.)80(10)678-684(2002) 6.Butmarc, J., Yufit, T., Carson, P., et al.Human β-defensin-2 expression is increased in chronic woundsWound Repair Regen.12(4)439-443(2004)

Aflatoxin B2-13C17(AFB2-13C17) is intended for use as an internal standard for the quantification of AFB2by GC- or LC-MS. AFB2is a mycotoxin that has been found inA. terricola.1It induces hepatic autophagy and apoptosis in broiler chickens when administered at doses of 0.2, 0.4, and 0.8 mg kg.2AFB2(0.5 and 1 mg animal) also induces parenchymal cell hyperplasia in rats.3 1.Moubasher, A.H., el-Kady, I.A., and Shoriet, A.Toxigenic Aspergilli isolated from different sources in EgyptAnn. Nutr. Aliment.31(4-6)607-615(1977) 2.Chen, B., Li, D., Li, M., et al.Induction of mitochondria-mediated apoptosis and PI3K Akt mTOR-mediated autophagy by aflatoxin B2 in hepatocytes of broilersOncotarget7(51)84989-84998(2016) 3.Wogan, G.N., Edwards, G.S., and Newberne, P.M.Structure-activity relationships in toxicity and carcinogenicity of aflatoxins and analogsCancer Res.31(12)1936-1942(1971)