m 084 hydrochloride

TRPC4/5 channel blocker (IC50 values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo. Zhu et al (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br.J.Pharmacol. 172 3495 PMID:25816897 |Yang et al (2015) Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One 10 e0136255 PMID:26317356

M084 (N-Butyl-1H-benzimidazol-2-amine) 是 TRPC4 5 通道的阻断剂，具有抗抑郁和抗焦虑作用。

M084 hydrochloride，是一种TRPC4/5通道阻滞剂，具有IC50值为10.3 μM (TRPC4)和8.2 μM (TRPC5)。此化合物展现出抗抑郁和抗焦虑样作用。