jcam 1

junctional adhesion molecule A (JAM-A), a cell adhesion molecule, is highly elevated in human GBM cancer stem cells and predicts poor patient prognosis. While JAM-A is also highly expressed in other cells in the tumor microenvironment, specifically microglia and macrophages,JAM-A functions to suppress pathogenic microglial activation in the female tumor microenvironment, highlighting an emerging role for sex differences in the GBM microenvironment and suggesting that sex differences extend beyond previously reported tumor cell-intrinsic differences.

JAM-A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.2 kDa and the accession number is O88792.

Expression system: HEK293 Cells
Length: 1-242, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-242, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-242, Partial
Activity: Not Tested