isolupalbigenin

Isolupalbigenin shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM), it also shows in vitro inhibitory activity toward human glyoxalase I. Isolupalbigenin shows two different antibacterial activities against MRSA: direct growth inhibition and intensification of methicillin sensitivity, it could lead to the development of compounds for new approaches against MRSA infection.

2'-Hydroxyisolupalbigenin 是一种异戊烯基异黄酮，可以从甘草（Glycyrrhiza uralensis）、白色羽扇豆 (Kievskij Mutant) 的中分离得到。2'-Hydroxyisolupalbigenin 具有PTP1B 抑制活性，IC₅₀ = 0.31–0.97 μM。