irucaparib-ap6

iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1. iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach.

NH2-PEG7 is a para-aminomethylbenzyloxycarbonyl (PROTAC) linker compound consisting of a polyethylene glycol (PEG) chain. It finds application in the synthesis of the PROTAC PARP1 degrader called iRucaparib-AP6[1].

Thalidomide-NH-PEG7 is a synthesized conjugate of an E3 ligase ligand and linker designed for use in antibody-drug conjugates (ADCs). This compound can be coupled to a protein ligand via a linker to create PROTAC iRucaparib-AP6, an extremely selective degrader of PARP1[1].