gsk3527497

GSK3527497 is a novel potent and selective inhibitor of transient receptor potential vanilloid-4 (TRPV4).

GSK3527497 is a potent and selective inhibitor of Transient Receptor Potential Vanilloid‑4 (TRPV4) with IC50 = 12 nM) for the treatment of heart failure and respiratory diseases. GSK3527497 is a preclinical candidate suitable for oral and iv administration that is projected to inhibit TRPV4 effectively in patients from a low daily clinical dose.

Z30529104 is a Rpn11 inhibitor.