gsk1842799

GSK1842799 is a selective S1P1 receptor agonist with good oral bioavailability.

GSK1842799 is a selective S1P1 receptor agonist for multiple sclerosis. Upon phosphorylation, GSK1842799 showed subnanomole S1P1 agonist activity with >1000× selectivity over S1P3. GSK1842799 demonstrated good oral bioavailability. On the basis of the favorable in vitro ADME and in vivo PK/PD properties as well as broad toxicology evaluations, GSK1842799 was selected as a candidate for further clinical.

MK-1775 hemihydrate is a WEE1 inhibitor with potential antineoplastic sensitizing activity.