grp

Gastrin-releasing peptide (GRP) is a neuropeptide that stimulates gastrin release. It binds to (Ki = 300 nM) and stimulates amylase secretion in rat pancreatic AR42J cells (EC50 = 0.3 nM). GRP increases proliferation of human liver carcinoma HepG2 and MHCC97H cells but does not affect the proliferation of normal HL-7702 liver cells at a concentration of 1 nM. In vivo, GRP (0.35 nmol/kg/h) increases both pancreatic exocrine secretion and pancreatic polypeptide (PP) release in rats. It dose-dependently stimulates gastrin, pancreatic amylase, lipase, bilirubin, and acid output and induces gallbladder contraction in humans when administered at doses ranging from 1 to 27 pmol/kg per hour.

Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice

Grp94 Inhibitor-1 是一种选择性有效的 Grp94抑制剂，IC50值为 2 nM，是比 Hsp90α 的 1000 倍。

GRP (porcine) acetate 是从猪胰腺中提取的胃泌素释放肽。 GRP (porcine) acetate 可能在猪胰腺内分泌和外分泌的副交感神经调节中起作用。

GRP-60367 hydrochloride is a novel small-molecule entry inhibitor of rabies virus (RABV), exhibiting nanomolar potency against select RABV strains. This first-in-class compound effectively targets the RABV G protein [1].

GRP (14-27) (human, porcine, canine) 表现为铃蟾肽受体配体。其特异性结合受到 GTP 和 GDP 的抑制作用，但 GMP 对此无影响。

GRP-60367 是一种小分子狂犬病病毒进入抑制剂，对某些 RABV 株具有纳摩尔作用效果。

Grp94 Inhibitor-3 (Compound C6) 是一种具有 5.52 μM 亲和力的选择性葡萄糖调节蛋白 94 (Grp94) 抑制剂。该化合物在原发性开角型青光眼以及转移性癌症研究中展现出应用前景。

GRP78-IN-1 displays interactions with specific residues on the GRP78 protein with a binding energy of -8.07 kcal mol. This compound possesses potent cytotoxic and anti-proliferative effects on cancer cells, particularly demonstrating promising apoptosis in breast cancer cells and wound healing properties [1].

GRP78-IN-2 是葡萄糖调节蛋白 78 (GRP78) 抑制剂，能够优先靶向细胞表面 GRP78，具有显著的的抗血管生成和抗癌作用，且不影响其他正常细胞。

GRP78-IN-3(化合物8)是一种有效的Hsp70底物结合的小分子竞争性抑制剂，是一种选择性的Grp78 (HSPA5)抑制剂，IC50为0.59 μM。GRP78-IN-3对HspA5的选择性是HspA9的7倍(IC50为4.3 μM)，对HspA5的选择性是HspA2的20倍(IC50为13.9 μM)。

Grp94-IN-2 is a inhibitor of Grp94.

GRP75-IN-1 hydrochloride (compound 33) 作为一种对抗子宫内膜癌 (Endometrial cancer, EC) 的化合物,具有诱导细胞凋亡的功能.该化合物通过针对GRP75并干扰其与 IP3R 的互动,有效降低线粒体内Ca2+的浓度.

Grp94 Inhibitor-2 (compound 23) 是一款具有高亲和力的环丙烷类似物,主要针对葡萄糖调节蛋白 94 (Grp94),其对 Grp94 和 Hsp90α 的 Kd 值分别为 0.48 µM 和 0.65 µM.

Anti-Human Mouse GRP78 Antibody (C38) 是一种来源于小鼠的 IgG2bkappa 抗体，专门针对 GRP78。其同型对照为 MouseIgG2bkappa, Isotype Control。

Human follicular gonadotropin releasing peptide (hF-GRP)是一种刺激垂体分泌促黄体激素(LH)及促卵泡激素(FSH)的激素类多肽，其作用可在体外实现。

CGRP antagonist 1是高效 CGRP 受体拮抗剂，Ki 值分别为 35nM，IC50 值为 57 nM。CGRP antagonist 1可用于研究心血管疾病和神经血管疾病。

CGRP (rat) acetateα-CGRP (rat) acetate（CGRP）。它是一种有效的血管扩张剂。

CGRP antagonist 6 (Compound 23) 作为一种高效的CGRP 受体拮抗剂, 其抑制常数 (Ki) 为0.84 nM, 主要用于偏头痛研究。

Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide . It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respectively). Tyr-α-CGRP also binds to and stimulates cAMP accumulation in rat L6 myocytes (IC50 = 4 nM; EC50 = 12 nM). It also binds to rat brain and spleen membrane preparations (IC50s = 0.2 and 0.5 nM, respectively), induces positive chronotropic and inotropic effects in isolated right and left guinea pig atria (EC50s = 282 and 74 nM, respectively), and inhibits the twitch response in rat vas deferens (EC50 = 1.9 nM).

Tyr-α-CGRP (rat) is an N-terminally tyrosinated analog of the neuropeptide α-CGRP that induces a fall in resting tension of isolated opossum internal anal sphincter (IAS) with an EC50 value of 178 nM.

GRPR antagonist-1 是胃泌素释放肽受体 (GRPR) 的有效拮抗剂，对某些癌细胞具有细胞毒性 (能够作用于 PC3 细胞 (IC50: 4.97 μM)、Pan02 细胞 (IC50: 4.36 μM)、HGC-27 细胞 (IC50: 3.40 μM))。GRPR antagonist-1 能够减少 Bcl-2 水平、提高 Bax 水平，进而抑制 HGC-27 细胞活力，使细胞凋亡，表现出抗癌效果。

GRPR antagonist-2 是胃泌素释放肽受体 (GRPR) 的有效拮抗剂，对某些癌细胞具有细胞毒性（能够作用于 HGC-27 细胞 (IC50: 0.77 μM) 和 Pan02 细胞 (IC50: 2.5 μM)），表现出抗癌效果。

α-CGRP, rat TFA 是一种神经肽 (降钙素基因相关肽)，主要表达于神经肌肉交界处，是一种有效的血管扩张剂量。α-CGRP, rat TFA 外周给药可使大鼠血压下降、心率升高，并使结肠平滑肌松弛。α-CGRP, rat TFA 可用于心血管、促炎、偏头痛和代谢相关的研究。