flupirtine

Flupirtine maleate (Katadolon maleate) 是可透过血脑屏障的、具有口服活性的非阿片类化合物。它是间接 NMDAR 拮抗剂，可用于缓解疼痛的研究，具有神经保护特性。

Flupirtine(D 9998)是神经元钾通道的选择性开放剂，并且具有NMDA 受体拮抗剂的特性。

Flupirtine HCl is the salt form of Flupirtine, also known as W-2964, an aminopyridine that functions as a centrally acting non-opioid analgesic. It first became available in Europe in 1984, and is sold mainly under the names Katadolon, Trancolong, Awegal, Efiret, Trancopal Dolo, and Metanor. Like nefopam, it is unique among analgesics in that it is a non-opioid, non-NSAID, non-steroidal centrally acting analgesic. Flupirtine is a selective neuronal potassium channel opener that also has NMDA receptor antagonist and GABAA receptor modulatory properties.

Flupirtine-D4 hydrochloride，Flupirtine hydrochloride的氘代物，为神经元钾通道开放剂，具有拮抗NMDA受体的作用。

Flupirtine-d6 (D 9998-d6) hydrochloride 是氘代标记的 Flupirtine hydrochloride。Flupirtine hydrochloride (D 9998 hydrochloride) 是一种选择性的神经钾通道开放剂，具有镇痛特性。它用于缓解各种疼痛状态，包括慢性肌肉骨骼疼痛、偏头痛和神经痛。Flupirtine hydrochloride 同时具备抗抑郁和抗氧化特点，并且在与吗啡联合使用时能增强镇痛作用。此外，它可以缓解异常的肌肉紧张，具有肌肉松弛的作用。在临床应用中，Flupirtine hydrochloride 相比其他药物如曲马多和潘妥昔，表现出更好的耐受性和较少的副作用。它对抑制神经过度兴奋表现出显著的功效，展现出在多种疼痛状态下的抑制潜力。