doc-1

Amino-PEG6-amido-C16-COOH, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].

Azido-C1-PEG3-C3-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized compound, designed as an E3 ligase ligand-linker conjugate, integrating the cereblon ligand derived from Pomalidomide and a linker employed in PROTAC technology. This compound serves to facilitate targeted protein degradation through the modulation of E3 ligase activity, enabling the selective elimination of specific proteins of interest.

Azide-PEG9-amido-C16-Boc is an alkyl ether-based PROTAC linker with utility in PROTAC synthesis [1].

Phenol-amido-C1-PEG3-N3, also known as PROTAC Linker 21, is a PEG-based linker utilized for synthesizing PROTACs.

Amino-PEG6-amido-C16-Boc is a PEG-based PROTAC linker employed for the synthesis of PROTACs[1].

Amino-PEG9-amido-C16-Boc is a polyethylene glycol (PEG)-based linker utilized for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Pomalidomide-amido-C1-Br is a synthesized conjugate consisting of the Pomalidomide-based cereblon ligand and a linker, functioning as an E3 ligase ligand-linker. This compound serves as a tool for designing a B-Raf PROTAC degrader, specifically PROTAC B-Raf degrader 1, which exhibits anti-cancer activity[1].

Azide-PEG6-amido-C16-Boc is an alkyl ether-based PROTAC linker utilized in PROTAC synthesis[1].

Azide-PEG9-amido-C12-Boc is a polyethylene glycol (PEG)-based proteolysis targeting chimera (PROTAC) linker used for the synthesis of PROTACs[1].