dimethyl f oicr 9429 cooh

Dimethyl-F-OICR-9429-COOH, a ligand for WD40 repeat domain protein 5 (WDR5). This compound is utilized as a key component in the synthesis of PROTACs.

OICR41114 (PROTAC4) 是一种针对WDR5的PROTAC降解剂。其能够降解内源性WDR5，EC50为40 nM，Dmax为49%。OICR41114 通过蛋白酶体依赖性机制降解HiBiT标记的WDR5。OICR41114由靶蛋白配体Dimethyl-F-OICR-9429-COOH、E3连接酶配体OICR-8268-acrylic acid和PROTAC linker Amino-PEG9-amine组成。其中，E3连接酶配体与linker形成的偶联物为OICR-8268-acrylic acid-amino-PEG9-amine。