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Targets Recommended: Antibacterial Parasite

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6452	Closantel Sodium	Antibacterial; Parasite	Microbiology/Virology
	Closantel sodium 是抗寄生虫活性的卤化水杨酰苯胺。它是高度特异性的盘尾丝虫几丁质酶抑制剂。
T0237	Closantel 氯氰碘柳胺,R-31520,氯生太尔	Antibacterial; Parasite	Microbiology/Virology
	Closantel (R-31520) 是抗寄生虫活性的卤化水杨酰苯胺。它是高度特异性盘尾丝虫几丁质酶抑制剂。
T40863	Bisdionin C	Antibacterial	Microbiology/Virology
	Bisdionin C 是一种有效的 GH18 chitinase 抑制剂，对 A. fumigatus ChiB1 的 IC50 为 0.2 μM。 Bisdionin C 抑制人巨噬细胞壳三糖苷酶 (HCHT, IC50 = 8.3 μM) 和酸性哺乳动物几丁质酶 (AMCase, IC50 = 3.4 μM)。
T9592	OATD-01	Others	Others
	OATD-01 是一种壳三糖苷酶及酸性哺乳动物几丁质酶的高活性抑制剂，对CHIT1具有低纳摩尔活性 (hCHIT1,IC50=23 nM)。它在多个物种中显示出良好的药代动力学特征，在体内具有显著的抗纤维化活性，可用于研究肺纤维化。
TP2140	Argifin	Others	Others
	Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms (IC50: 0.025 μM, 6.4 μM, 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase).
T9952	OAT-2068	Others	Others
	OAT-2068 是一种有效且选择性的小鼠壳三糖苷酶 (CHIT1) 抑制剂，与 mAMCase 相比，mCHIT1 的选择性高出 143 倍。
T37570	4-Methylumbelliferyl-β-D-N,N',N''-Triacetylchitotrioside
	4-Methylumbelliferyl-β-D-N,N',N''-triacetylchitotrioside is a fluorogenic substrate for chitinases and chitotriosidases. 4-Methylumbelliferyl-β-D-N,N',N''-triacetylchitotrioside is cleaved by chitinases and chitotriosidases to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. ...

化合物

Closantel Sodium

Cat.No: T6452

Synonym:

Target: Antibacterial, Parasite

Closantel

Cat.No: T0237

Synonym: 氯氰碘柳胺,R-31520,氯生太尔

Target: Antibacterial, Parasite

Bisdionin C

Cat.No: T40863

Synonym:

Target: Antibacterial

4-Methylumbelliferyl-β-D-N,N',N''-Triacetylchitotrioside

Cat.No: T37570

Synonym:

Target:

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01290	CHIT1 Protein, Human, Recombinant (His) chitinase 1 (chitotriosidase),CHITD,CHI3,CHIT	Human	HEK293 Cells
	Chitotriosidase, also known as Chitinase-1 and CHIT1, is a member of the glycosyl hydrolase 18 family and Chitinase class II subfamily. It is a member of the mammalian chitinase family, structurally homologous to chitinases from other species, is synthesized and secreted by specifically activated macrophages. Chitotriosidase is a polymer of N-acetylglucosamine. Serum and plasma chitotriosidase activity is usually measured as the first step in diagnosis of Gaucher disease. Monitoring chitotriosid...
TMPK-01127	AMCase/CHIA Protein, Mouse, Recombinant (His) CHIT2,Chia1,AMCase,YNL,Acidic mammalian chitinase,CHIA,EC 3....	Mouse	HEK293 Cells
	Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT-1) are two active chitinases expressed in humans. The chitinase activity of AMCase was found to be causative in allergic inflammation and its expression was found to be induced by interleukin-13. CHIT1-1 is expressed by phagocytic cells and extremely high levels are seen in lysosomal storage diseases. The expression of AMCase and CHIT-1 were differently modulated in HMMs at different stage of maturation.
TMPK-01154	AMCase/CHIA Protein, Human, Recombinant (His) YNL,AMCase,Chia1,CHIA,Acidic mammalian chitinase,EC 3.2.1.14...	Human	HEK293 Cells
	Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT-1) are two active chitinases expressed in humans. The chitinase activity of AMCase was found to be causative in allergic inflammation and its expression was found to be induced by interleukin-13. CHIT1-1 is expressed by phagocytic cells and extremely high levels are seen in lysosomal storage diseases. Despite that AMCase expression in the inflammation is under investigation, little is known regarding its regulation during macrophages'...