bromamphenicol

Bromamphenicol is a dibrominated derivative of the antibiotic chloramphenicol. It inhibits rat liver mitochondrial and E. coli protein synthesis by 90.6 and 98.8%, respectively, when used at a concentration of 93 μM, and inhibits DNA synthesis in human lymphoblastoid cells by 83% at 1 mM. Bromamphenicol can also bind to the major adhesin subunit DraE from E. coli.

(Rac)-Bromamphenicol是Bromamphenicol的外消旋体，Bromamphenicol (Compound Ib) 为Chloramphenicol的衍生物，具抗菌效能。Bromamphenicol结合S50核糖体亚基，干扰肽基转移酶活性，抑制蛋白质合成。