BDZ-h is a potent inhibitor of both the closed-channel and the open-channel conformations of all four homomeric AMPA receptor channels and two GluA2R containing complex AMPA receptor channels.
Afabicin (formerly Debio 1450, AFN-1720) is a prodrug of afabicin desphosphono, an enoyl-acyl carrier protein reductase (FabI) inhibitor, and is a first-in-class antibiotic with a novel mode of action to specifically target fatty acid synthesis in Staphylococcus spp.