b α chain

Mebendazole (Mebenvet) 是一种 hedgehog 抑制剂，用作驱虫药。

Insulin β Chain Peptide (15-23), also referred to as INS, is an insulin-derived peptide that is specifically recognized by islet-associated T cells. The tetramer of Insulin β Chain Peptide (15-23) effectively stained the INS-reactive CTL clone G9C8; however, neither this tetramer nor the negative control tetramer (TUM) exhibited staining on the splenic CD8+ T cells obtained from NOD or 8.3-TCRαβ transgenic NOD mice.

Thrombin is a "trypsin-like" serine protease that is encoded by the F2 gene in humans. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). Thrombin in turn acts as a serine protease that converts soluble

InsB (9-23)（InsulinB chain (9-23)）是一种胰岛素 B 链肽，能够与 II 类组织相容性复合体 (MHC) 等位基因 I-Ag7 结合。InsB (9-23) 在 I 型糖尿病等多种自身免疫疾病的研究中展现了潜在价值。

TNF-α-IN-18是一种肿瘤坏死因子-α (TNF-α) 的抑制剂，其 IC50 为 1.8µM。TNF-α-IN-18有效阻断核因子 κB (NF-κB) 的核转位，从而抑制下游 TNF 信号通路。在小鼠成纤维 LM 细胞中表现出最小细胞毒性 (CC50 大于 50 µM)。研究证实 TNF-α-IN-18 能缓解小鼠模型中 TNF 或脂多糖诱导的脓毒症，并对类风湿关节炎的发展提供显著保护作用。