arn 077

ARN 077 is a selective N-acylethanolamine acid amidase (NAAA) inhibitor (IC50: 7 nM for human NAAA). ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS.

ARN 077 enantiomer (19) 是 ARN 077 的低活性异构体，其在大鼠中的 NAAA IC50 值为 3.53 μM。