anguinomycin a

Anguinomycin A is an antibiotic first isolated from a Streptomyces sp. and analog of leptomycin B that is highly cytotoxic to mouse P388 leukemia cells in vitro (IC50 = 0.1-0.2 ng/ml). It also demonstrates antitumor activity at 62.5 μg/kg/day against Lewis lung carcinoma in mice.

Anguinomycin B 是一种抗肿瘤抗生素 (antibiotic)，对小鼠 P388 白血病细胞展现出极强的细胞毒性。