amino-peg5-boc

Amino-PEG5-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Carboxy-Amido-PEG5-N-Boc 是一种带有末端羧酸和 Boc 保护氨基的 PEG 连接体。其亲水性的 PEG 间隔物能够提升在水性介质中的溶解度。在活化剂（例如 EDC、HATU）存在下，末端羧酸能够与一级胺基团反应，生成稳定的酰胺键。Boc 基团在温和酸性条件下可脱保护，产生游离胺。