aclacinomycin

Aclacinomycin A is an anthracycline drug. It sensitizes K562 chronic myeloid leukemia cells to imatinib through p38MAPK-mediated erythroid differentiation. It is used in the treatment of cancer.

Aclacinomycin A hydrochloride(Aclarubicin HCl)是一种蒽环类抗生素和topoisomerase I II的抑制剂，干扰DNA转录和复制，抑制肿瘤侵袭和血管生成，生成ROS，抑制20S蛋白酶体催化中心，可用于复发性白血病和晚期恶性淋巴瘤。

Aclacinomycin A (Aclarubicin) 是一种从加利莱链霉菌中分离出的新型蒽环类抗生素，具有抗肿瘤活性。Aclacinomycin A 是拓扑异构酶 I 和 II 的抑制剂，抑制 RNA 活性 。Aclacinomycin A 可用于研究复发性白血病和晚期恶性淋巴瘤。

2-Hydroxyaclacinomycin A 是蒽环类抗生素，能够抑制白血病 L-1210 细胞，其对 RNA 和 DNA 合成的半数抑制浓度（IC50）分别为 0.10 μg/mL 和 0.95 μg/mL。

10-Decarbomethoxyaclacinomycin A 是一种蒽环类抗生素，由突变株 Streptomyces galilaeus MA144-Mlt KE303 生产，具备抗菌活性。

2-Hydroxyaclacinomycin B 是一种蒽环类抗生素，存在于 Streptomyces galilaeus A-862 (加利利链霉菌) (FERM BP-45) 中。该化合物显著抑制RNA合成(RNA synthesis)，并具有抗肿瘤活性。

Antibiotic MA 144M2 is an anthracycline glycoside that inhibits the growth of gram-positive bacteria, e.g. Staphyococcus aureaus, Bacillus subtilis and Sarcina lutea, and inhibits the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180. It's produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.

Antibiotic MA 144M1 is an anthracycline glycoside that inhibits the growth of gram-positive bacteria, e.g. Staphyococcus aureaus, Bacillus subtilis and Sarcina lutea, and inhibits the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180. It's produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.