a57219

Norendoxifen, also known as 4-hydroxy-N, N-didesmethyltamoxifen, is a nonsteroidal aromatase inhibitor of the triphenylethylene group that was never marketed. It is an active metabolite of the selective estrogen receptor modulator tamoxifen.

Nemazoline hydrochloride (A-57219 hydrochloride) 是一种选择性 α-肾上腺素能 (α-adrenergic) 剂，具备α1- 激动剂和α2- 拮抗剂的特性，主要用于作为鼻减充血剂。该化合物通过α1- 介导的容量血管收缩缓解鼻塞，同时由于α2- 拮抗作用，不影响血流。此外，Nemazoline hydrochloride 能够阻止内源性去甲肾上腺素介导的α2- 对抵抗血管的收缩。