a 1293201

Glutathione maleimide is a hydrophilic derivative of the protein tyrosine phosphatase inhibitor phenylarsine oxide (PAO). It inhibits angiogenesis and tumour growth.

A-1293201是一种强效、选择性的 Bfl-1/A1 抑制剂 (IC50 = 16 nM)。它通过特异性结合 Bfl-1 疏水凹槽，中和其抗凋亡功能并增强血液肿瘤细胞对化疗药物的敏感性，用于克服耐药性研究。