TCO-PEG6-amine

TCO-PEG6-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Tetrazine-PEG6-amine (hydrochloride) 是一种配备 6 个单元的 PEG 药物偶联试剂，广泛应用于抗体药物偶联物 (ADC) 的制备。此化合物作为点击化学试剂，含有 Tetrazine 基团，能够通过逆电子需求 Diels-Alder 反应（iEDDA）与含 TCO 基团的分子快速发生反应。