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Cat. No.	Product Name	Target	Signaling Pathways
TP1257L	Adrenomedullin (AM) (22-52), human acetate Adrenomedullin (AM) (22-52), human acetate（159899-65-7 Free base）	CGRP Receptor	GPCR/G Protein; Neuroscience
	Adrenomedullin (AM) (22-52), human acetate 是猫后肢血管床中 CGRP 受体和肾上腺髓质素受体的拮抗剂。
TP1257	Adrenomedullin (AM) (22-52), human 22-52-Adrenomedullin (human)
	Adrenomedullin (ADM) is a 52-aa hypotensive peptide. Adrenomedullin (ADM) has structural similarity with amylin.
TP1146	Adrenomedullin (AM) (1-52), human Human adrenomedullin-(1-52)-NH2
	Adrenomedullin (AM) (1-52), human is a 52-amino acid peptide that modulates cellular proliferation and angiogenesis in cancer.
TP1145	Adrenomedullin (AM) (1-52), human TFA Human adrenomedullin-(1-52)-NH2 (TFA)
	Adrenomedullin (AM) (1-52), human (TFA) is an NH2 terminal truncated adrenomedullin analogue,affects cell proliferation and angiogenesis in cancer.
TP1256	Adrenomedullin (AM) (22-52), human TFA 22-52-Adrenomedullin (human) (TFA)
	Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin human) TFAis a kind of NH2 TFA truncated at the end of the quality of adrenal medullary analogue, is a kind of quality of adrenal medullary receptor antagonist.
TP1486	Adrenomedullin (16-31), human
	Adrenomedullin (16-31), human is amino acid residues 16-31 fragment of human adrenomedullin (hADM).
TP1764	Adrenomedullin (1-50), rat
	Adrenomedullin (1-50), rat is a 50 amino acid peptide, which induces a selective arterial vasodilation via activation of CGRP1 receptor. Adrenomedullin (1-50) is a peptide hormone with RNA expressed in rat adrenal glands, lung, kidney, heart, and spleen,
T36565	Adrenomedullin (13-52) (human) (trifluoroacetate salt)
	Adrenomedullin (13-52) is a truncated form of adrenomedullin (1-52) . It induces nitric oxide-dependent relaxation of and inhibits release of angiotensin II and endothelin-1 from isolated rat aorta. In vivo, adrenomedullin (13-52) decreases mean arterial pressure (MAP) in spontaneously and renal hypertensive rats in a dose-dependent manner. Adrenomedullin (13-52) (10-3,000 ng per animal) reverses increases in lobar arterial pressure induced by U-46619 in a dose-dependent manner in cats but has n...
T35858	Adrenomedullin (22-52) (human) (trifluoroacetate salt)
	Adrenomedullin (22-52) is a C-terminal fragment of adrenomedullin (1-52) . In vitro, adrenomedullin (22-52) reduces basal corticosterone production in a mixture of rat adrenocortical and adrenomedulllary cells. It also reverses increases in ACTH-stimulated corticosterone production induced by adrenomedullin (1-52). Adrenomedulin (22-52) (0.5 and 5 μg/kg/min) has no effect on basal regional cerebral blood flow but reverses increases in regional cerebral blood flow induced by rat adrenomedullin in...
TP1625	Adrenomedullin (11-50), rat
	Adrenomedullin 11-50 rat is a peptide fragment of adrenomedullin that possesses systemic vasodilator activity at the level of calcitonin gene-related peptide-1 (CGRP1) receptor activation. Adrenomedullin and its peptide may be used in bone growth studies.
T36405	Pro-Adrenomedullin (153-185), human Pro-Adrenomedullin (153-185), human,H2N-Ser-Leu-Pro-Glu-Ala-Gly-Pro-Gly-Arg-Thr-Leu-Val-Ser-Ser-Lys-Pro-Gln-Ala-His-Gly-Ala-Pro-Ala-Pro-Pro-Ser-Gly-Ser-Ala-Pro-His-Phe-Leu-OH
	Pro-Adrenomedullin(153-185),human, (C143H224N42O43), a peptide with the sequence H2N-SLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL-OH, MW= 3219.6. Adrenomedullin (AM) is a ubiquitously expressed peptide initially isolated from phaechromyctoma in 19931. AM was initially identified as a vasodilator, some have cited this as the most potent endogenous vasodilatory peptide found in the body2. Differences in opinion regarding the ability of AM to relax vascular tone arises from the differences in the model system...
TP2214	Adrenomedullin (1-12), human	Others	Others
	Adrenomedullin (AM) (1-12), human, is a peptide with the sequence Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg. Adrenomedullin (AM) (1-12), human, was initially identified as a vasodilator, and as such, it has the ability to relax vascular tone. Other
TP1857	Adrenomedullin (AM) (13-52), human
	Adrenomedullin (13-52) is a 40 amino acid peptide with one intramolecular disulfide bridge, Adrenomedullin (13-52) is a high affinity ligand for the adrenomedullin receptor.
T83163	Adrenomedullin (rat)
	Adrenomedullin(rat) 为一种由内皮细胞（EC）与血管平滑肌细胞（VSMC）分泌的有效血管舒张肽。
T83164	Adrenomedullin (porcine)
	Adrenomedullin(porcine)是一種多肽，具有调节血管舒张的功能。它在内皮依赖性条件下能诱导大鼠主动脉舒张，IC50为2.4 nM；在内皮非依赖性条件下则能诱导猪冠状动脉舒张，IC50为27.6 nM。
T76011	Adrenomedullin (16-31), human TFA
	Adrenomedullin(16-31), human TFA 为人类肾上腺髓质素(hADM)之16至31氨基酸片段，对CGRP1受体显示高亲和力。该化合物在大鼠体内可提高全身血压，但对猫无效。
T80503	Proadrenomedullin (N-20) (bovine, porcine) ProADM N20(bovine, porcine),PAMP-20(bovine, porcine)
	Proadrenomedullin (N-20) (bovine, porcine) 是一种来源于嗜铬细胞的、具有降压及抑制 catecholamine release 的非竞争性肽类。该化合物能显著抑制 PC12 嗜铬细胞瘤细胞的 catecholamine 分泌，显示出 350 nM 的 IC50 值。此外，Proadrenomedullin (N-20) (bovine, porcine) 作为 EC50 约为 270 nM 的阻断剂，能够有效抵抗烟碱能激动剂引起的 catecholamine release 脱敏现象和烟碱相关的信号通道 (22Na+摄取)。
TP1488	Proadrenomedullin (45-92), human
	Proadrenomedullin (45-92), human, a mid-regional fragment of proadrenomedullin (MR-proADM), comprises amino acids 45–92 of pre-proADM.
TP1490	Proadrenomedullin (1-20), human
	Endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrena
TP2135L	cAC 253 acetate cAC 253 acetate (TP2135 Free base)	Amylin Receptor	GPCR/G Protein
	cAC 253 acetate (TP2135 Free base) 是 amylin 的拮抗剂，抑制 125I-adrenomedullin 结合，其IC50 值为 25 nM。
T23521	VULM 1457	Acyltransferase	Metabolism
	VULM 1457 是有效的胆固醇酰基转移酶抑制剂，具有显著的降血脂活性，并改善了整体心肌缺血再灌注损伤结果。VULM 1457 显著降低肾上腺髓质素的产生和分泌，并下调人肝母细胞上的 AM 受体。VULM 1457 具有研究糖尿病和高胆固醇血症的潜力。
T4200	Sacubitril hemicalcium salt AHU-377 (hemicalcium salt),LCZ696中间体,AHU377 calcium salt	Neprilysin	Metabolism
	Sacubitril hemicalcium salt (AHU377 calcium salt) 是一种有效的 NEP 抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。
T76473	Adrenotensin (human)
	Adrenotensin (human) (Pro-ADM-153-185 (human)) 是一种肾上腺髓质素前体肽的特定片段，具体为153至185位点。Adrenotensin (ADM)作为一个含有52个氨基酸的多功能肽，隶属于血管活性肽激素CGRP超家族。
T81557	PAMP-12(human, porcine) TFA
	PAMP-12(human, porcine) TFA，免疫反应性PAMP(ir-PAMP)的关键成分，源自肾上腺髓质素前体，具有调节心血管功能和显著降压作用的生物活性肽。
TP2049	CRSP-1
	Endogenous central calcitonin (CT) receptor agonist that stimulates cAMP formation at a potency 350-fold greater than CT (ED50 values are 0.2 and 71 nM respectively). Displays no activity at calcitonin-gene related peptide (CGRP) and adrenomedullin recept
T68511	KRH102140
	KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH102140 decreased the mRNA levels of HIF-regulated downstream target genes associated with angiogenesis and energy metabolism such as vascular endothelial growth factor, adrenomedullin, Glut1, aldolase A, enolase 1 and monocarboxylate transporter 4. KRH102140 also inhibited tube format...
T37413	Calcitonin (salmon) (trifluoroacetate salt)
	Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption. It belongs to the calcitonin family of peptides, which also includes amylin , calcitonin gene-related peptide , and adrenomedullin. The binding of salmon calcitonin to the human calcitonin receptor (CTR) is not modulated by receptor activity-modifying proteins (RAMPs), which influence affinity of human calcitonin to CTR. Salmon calcitonin binds to human CTR2 with IC50 values of 0.933, 0.224, 0.134, and ...
TP2049L	CRSP-1 acetate(697327-12-1 Free base)
	CRSP-1 acetate(697327-12-1 Free base) 是一种内源性中枢降钙素(CT)受体激动剂，其刺激cAMP形成的效力是CT的350倍（ED50值分别为0.2和71nM）。CRSP-1 acetate 对降钙素基因相关肽 (CGRP) 和肾上腺髓质素受体没有活性。CRSP-1 acetate 抑制多核破骨细胞的形成，其体外功效与CT相似。CRSP-1 acetate 抑制自由进食大鼠的食物摄入并升高体温，并显着降低体内血浆钙水平。

化合物

Adrenomedullin (AM) (22-52), human acetate

Cat.No: TP1257L

Synonym: Adrenomedullin (AM) (22-52), human acetate（159899-65-7 Free base）

Target: CGRP Receptor

Adrenomedullin (AM) (22-52), human

Cat.No: TP1257

Synonym: 22-52-Adrenomedullin (human)

Adrenomedullin (AM) (1-52), human

Cat.No: TP1146

Synonym: Human adrenomedullin-(1-52)-NH2

Adrenomedullin (AM) (1-52), human TFA

Cat.No: TP1145

Synonym: Human adrenomedullin-(1-52)-NH2 (TFA)

Adrenomedullin (AM) (22-52), human TFA

Cat.No: TP1256

Synonym: 22-52-Adrenomedullin (human) (TFA)

Adrenomedullin (16-31), human

Cat.No: TP1486

Adrenomedullin (1-50), rat

Cat.No: TP1764

Adrenomedullin (13-52) (human) (trifluoroacetate salt)

Cat.No: T36565

Adrenomedullin (22-52) (human) (trifluoroacetate salt)

Cat.No: T35858

Adrenomedullin (11-50), rat

Cat.No: TP1625

Pro-Adrenomedullin (153-185), human

Cat.No: T36405

Synonym: Pro-Adrenomedullin (153-185), human,H2N-Ser-Leu-Pro-Glu-Ala-Gly-Pro-Gly-Arg-Thr-Leu-Val-Ser-Ser-Lys-Pro-Gln-Ala-His-Gly-Ala-Pro-Ala-Pro-Pro-Ser-Gly-Ser-Ala-Pro-His-Phe-Leu-OH

Adrenomedullin (1-12), human

Cat.No: TP2214

Target: Others

Adrenomedullin (AM) (13-52), human

Cat.No: TP1857

Adrenomedullin (rat)

Cat.No: T83163

Adrenomedullin (porcine)

Cat.No: T83164

Adrenomedullin (16-31), human TFA

Cat.No: T76011

Proadrenomedullin (N-20) (bovine, porcine)

Cat.No: T80503

Synonym: ProADM N20(bovine, porcine),PAMP-20(bovine, porcine)

Proadrenomedullin (45-92), human

Cat.No: TP1488

Proadrenomedullin (1-20), human

Cat.No: TP1490

cAC 253 acetate

Cat.No: TP2135L

Synonym: cAC 253 acetate (TP2135 Free base)

Target: Amylin Receptor

Cat.No: T23521

Target: Acyltransferase

Sacubitril hemicalcium salt

Cat.No: T4200

Synonym: AHU-377 (hemicalcium salt),LCZ696中间体,AHU377 calcium salt

Target: Neprilysin

Adrenotensin (human)

Cat.No: T76473

PAMP-12(human, porcine) TFA

Cat.No: T81557

Cat.No: TP2049

Cat.No: T68511

Calcitonin (salmon) (trifluoroacetate salt)

Cat.No: T37413

CRSP-1 acetate(697327-12-1 Free base)

Cat.No: TP2049L

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