8bromocyclic amp

8-Bromo-cAMP是一种细胞渗透性cAMP类似物，也是CAMP-dependent protein kinase A(CAMP依赖性蛋白激酶A)的激活剂，能够诱导细胞死亡和减少增殖。

Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart.