5-oxoete

5-OxoETE (5-KETE) 是一种多不饱和脂肪酸衍生物，是嗜酸性粒细胞的趋化因子，是肠易激综合征的潜在生物标志物。5-OxoETE 通过磷脂酶 C（PLC）和百日咳毒素依赖性机制选择性刺激非肽能、异凝集素 B4 （IB4） 阳性 DRG 神经元，可用于研究哮喘、癌症和心血管疾病。

5-OxoETE methyl ester is an esterified form of the polyunsaturated keto acid 5-oxoETE . 5-OxoETE methyl ester is an agonist of oxoeicosanoid receptor 1 (OXER1; EC50 = 1.54 μM for β-arrestin recruitment) that has a higher maximal response than 5-oxoETE in a β-arrestin assay.

15-OxoETE is produced by oxidation of the 15-hydroxyl of 15-HETE. Whether this is a major pathway of 15-HETE metabolism is yet to be clearly established.

15-OxoEDE, generated through the oxidation of 15-HEDE, effectively inhibits 5-LO in RBL-1 cells with an IC50 of 55 µM, approximately half as potent as 15(S)-HEDE. Additionally, another related oxo-eicosanoid, 5-oxoETE, is produced from 5(S)-HETE via a specific dehydrogenase, exhibiting significant inflammatory activity.