21deoxycortisol

21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies.

21-Deoxycortisol-d8 是 21-Deoxycortisol 的氘代化合物。21-Deoxycortisol 的 CAS 号为 641-77-0。

21-Deoxycortisol (Standard) 是一种可用于分析的标准物质，通常用作 21-Deoxycortisol 的研究和分析中参考的标准样品。21-Deoxycortisol 是 17-羟孕酮的一种皮质类固醇代谢产物，由肾上腺通过 11-羟化作用由 11β-羟化酶生成。在患有先天性肾上腺增生症且 CYP2A21 基因（编码类固醇 21-羟化酶的基因）发生杂合突变的患者中，其血清 21-脱氧皮质醇水平会升高，并且已被用作检测 21-羟化酶缺陷的生物标志物。