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HE4 Protein, Canine, Recombinant (hFc)

产品编号 TMPY-03199

别名: WAP four-disulfide core domain 2

HE4 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.3 kDa and the accession number is Q28894.

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HE4 Protein, Canine, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 4,460		5日内发货

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生物活性	Testing in progress
产品描述	HE4 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.3 kDa and the accession number is Q28894.

种属	Canine
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q28894
别名	WAP four-disulfide core domain 2
蛋白构建	The canine WFDC2 (NP_001003241.1)(Met1-Phe124) was expressed, fused with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	37.3 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	WAP four-disulfide core domain protein 2, also known as Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2 and HE4, is a secreted protein that contains two WAP domains. WFDC2 / HE4 is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. It is expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. WFDC2 may be a component of the innate immune defences of the lung, nasal and oral cavities and suggest that WFDC2 functions in concert with related WAP domain containing proteins in epithelial host defence. WFDC2 re-expression in lung carcinomas may prove to be associated with tumour type and should be studied in further detail. Mammary gland expression of tammar WFDC2 during the course of lactation showed WFDC2 was elevated during pregnancy, reduced in early lactation and absent in mid-late lactation. WFDC2 / HE4 can undergo a complex series of alternative splicing events that can potentially yield five distinct WAP domain containing protein isoforms.

参考文献

1. Bingle,L. et al., 2002, Oncogene. 21 (17):2768-73. 2. Hellström,I. et al., 2003, Cancer Res. 63 (13):3695-700. 3. Bingle,L. et al., 2006, Respir Res. 7 : 61. 4. Galgano,M.T. et al., 2006, Mod Pathol.19 (6):847-53. 5. Sharp,J.A. et al., 2007, Evol Dev. 9 (4): 378-92.

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Keywords

HE4 Protein, Canine, Recombinant (hFc) WAP four-disulfide core domain 2 recombinant recombinant-proteins proteins protein

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