Name: ENSA Protein, Human, Recombinant (His), Biotinylated
Brand: TargetMol
SKU: TMPY-05654
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 μg

¥ 693

6-8日内发货

10 μg

¥ 1,170

6-8日内发货

20 μg

¥ 1,950

5日内发货

50 μg

¥ 3,200

5日内发货

100 μg

¥ 5,350

5日内发货

生物活性

产品描述	ENSA Protein, Human, Recombinant (His), Biotinylated is expressed in E. coli expression system with His tag. The predicted molecular weight is 15.2 kDa and the accession number is O43768-1.
生物活性	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景	Endosulfine alpha, also known as ENSA, belongs to the endosulfine family. It is a highly conserved cAMP-regulated phosphoprotein (ARPP) family. Endosulfine alpha is widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. As a protein phosphatase inhibitor, ENSA specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase By similarity. Endosulfine alpha also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
种属	Human
表达系统	E. coli
标签	N-His
蛋白编号	O43768-1
蛋白构建	A DNA sequence encoding the mature form of human ENSA (O43768-1) (Met1-Glu121) was expressed with a polyhistide tag at the N-terminus. The purified protein was biotinylated in vitro. Predicted N terminal: His
蛋白纯度	> 90 % as determined by SDS-PAGE
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
别名	endosulfine α, endosulfine alpha, ARPP-19e
内毒素	Please contact us for more information.