Cyclin O (encoded by CCNO) is a member of the cyclin family with regulatory functions in ciliogenesis and apoptosis. Homozygous CCNO mutations have been identified in human patients with Reduced Generation of Multiple Motile Cilia (RGMC) and conditional inactivation of Ccno in the mouse recapitulates some of the pathologies associated with the human disease. These include defects in the development of motile cilia and hydrocephalus. Elevated CCNO expression is closely associated with human gastric cancer (GC) development and that CCNO knockdown could efficiently inhibit the malignant properties of GC cells by inducing cell apoptosis. CCNO could be used as a potential biomarker for prognosis or even as a therapeutic target in human GC.

>95% as determined by SDS-PAGE.